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Metabolomics in Drug Response and Addiction

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Addiction Medicine

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Abstract

Metabolomics together with genomics and proteomics contribute towards a better understanding of biological processes including addiction through a modern integrative approach known as systems biology. The excessive economic and social cost of drug addiction necessitates better understanding of how these drugs function and how they elicit variable response in the human body. Numerous studies involving animals and humans indicate that in addition to environmental factors, various genetic and metabolomic factors working in various signaling and interacting pathways in the brain play critical roles in mechanisms underlying drug addiction. The availability of the complete genome sequences, emergence of latest high throughput technologies and the development of powerful bioinformatics tools and applications allow researcher to seek novel approaches to understand these mechanisms. Several important integrative approaches are discussed in this chapter, for example, construction of biological interaction network and pathways from microarray data and construction of transcription regulatory network including their use in solving drug addiction disorders.

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Authors and Affiliations

  1. Molecular Genetics Unit, Department of Biology, University of Western Ontario, London, ON, N6A5B7, Canada

    Raihan K. Uddin & Shiva M. Singh

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  1. Raihan K. Uddin
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  2. Shiva M. Singh
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Correspondence to Raihan K. Uddin .

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  1. , Depts Psychiat & Neurobehav Sciences, Me, University of Virginia, Charlottesville, 22908, Virginia, USA

    Bankole A. Johnson

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Uddin, R.K., Singh, S.M. (2010). Metabolomics in Drug Response and Addiction. In: Johnson, B. (eds) Addiction Medicine. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-0338-9_12

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  • DOI: https://doi.org/10.1007/978-1-4419-0338-9_12

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