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Molecular Mechanisms of Spondyloarthropathies pp 122–132Cite as

Biomarkers in Spondyloarthropathies

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Part of the book series: Advances in Experimental Medicine and Biology ((volume 649))

Abstract

The study of biomarkers in spondyloarthropathy (SpA) has emerged to be a very important field of research. This is particularly because the two commonly used biomarkers, erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP), are of very low sensitivity and specificity. The second reason is, with advances in the treatment of SpA by the very expensive tumor necrosis factor-α (TNF-α) blockers, for cost-effectiveness, clinicians need to be much more accurate in predicting disease progression, evaluating disease activity and monitoring therapeutic efficacy. This review focuses on several biomarkers of promise: matrix metalloproteinases 3 (MMP-3), Type II collagen neoepitope (C2C and C1-2C), C-propeptide of Type II collagen (CPII), aggrecan 846 epitope, macrophage colony stimulating factor (M-CSF), serum amyloid A (SAA) and Interleukin-6 (IL-6). The results summarized in Table 1 call for a co-ordinated effort for systematic studies of existing biomarkers and for search for new candidates.

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Author information

Authors and Affiliations

  1. Institute of Clinical Medicine, National Yang-Ming University and Veterans General Hospital, Taipei, Taiwan

    Chun-Hsiung Chen

  2. Rheumatology Division Rehabilitation Center, University of California, Los Angeles, California, USA

    David Tak Yan Yu

  3. Division of Allergy, Immunology and Rheumatology, Veterans General Hospital, Taipei, Taiwan

    Chung-Tei Chou

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  1. Chun-Hsiung Chen
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  2. David Tak Yan Yu
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  3. Chung-Tei Chou
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Editors and Affiliations

  1. Hospital Universitario Central de Asturias, Oviedo, Spain

    Carlos López-Larrea PhD  & Roberto Díaz-Peña BSc  & 

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Chen, CH., Yu, D.T.Y., Chou, CT. (2009). Biomarkers in Spondyloarthropathies. In: López-Larrea, C., Díaz-Peña, R. (eds) Molecular Mechanisms of Spondyloarthropathies. Advances in Experimental Medicine and Biology, vol 649. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-0298-6_9

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