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Molecular Mechanisms of Spondyloarthropathies pp 148–158Cite as

Genomewide Screens in Ankylosing Spondylitis

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Part of the book series: Advances in Experimental Medicine and Biology ((volume 649))

Abstract

Efforts to identify genes other than HLA-B27 in AS have been driven by the strength of the evidence from genetic epidemiology studies indicating that HLA-B27, although a major gene in AS, is clearly not the only significant gene operating. This is the case for both genetic determinants of disease-susceptibility and phenotypic characteristics such as disease severity and associated disease features. In this chapter the genetic epidemiology of AS and the gene-mapping studies performed to date will be reviewed and the future direction of research in this field discussed.

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Authors and Affiliations

  1. Diamantina Institute of Cancer, Immunology and Metabolic Medicine, Princess Alexandra Hospital, Ipswich Road, Wooloongabba, Qld, 4102, Australia

    Matthew A. Brown

  2. Botnar Research Center Nuffield Orthopaedic Center, University of Oxford Institute of Musculoskeletal Sciences, Headington, Oxford, UK

    Matthew A. Brown

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  1. Matthew A. Brown
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  1. Hospital Universitario Central de Asturias, Oviedo, Spain

    Carlos López-Larrea PhD  & Roberto Díaz-Peña BSc  & 

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Brown, M.A. (2009). Genomewide Screens in Ankylosing Spondylitis. In: López-Larrea, C., Díaz-Peña, R. (eds) Molecular Mechanisms of Spondyloarthropathies. Advances in Experimental Medicine and Biology, vol 649. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-0298-6_11

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