Abstract
Osteosarcoma is the most common primary bone malignancy in the United States, comprising approximately 56% of the primary bone tumors.1,2 Most patients present with local disease; their treatment is outlined in greater detail elsewhere in this book. However, 10–20% of patients diagnosed with osteosarcoma will have radiographic evidence of synchronous isolated pulmonary metastases at the time of initial presentation. Of the patients without synchronous pulmonary metastases, 40–55% will develop metachronous pulmonary metastases.3–5
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsReferences
Wang, LL, Chintagumpala, M, and Gebhardt, MC. Osteosarcoma: epidemiology, pathogenesis, clinical presentation, diagnosis, and histology. Uptodate. 2007.
National Cancer Institute. Cancer Incidence and Survival among Children and Adolscents: United States SEER Program 1975–1995. 1995;89-110.
Ward WG, Mikaelian K, Dorey F, et al. Pulmonary metastases of stage IIB extremity osteosarcoma and subsequent pulmonary metastases. J Clin Oncol. 1994;12:1849-1858.
Harting MT, Blakely ML, Jaffe N, et al. Long-term survival after aggressive resection of pulmonary metastases among children and adolescents with osteosarcoma. J Pediatr Surg. 2006;41:194-199.
Tsuchiya H, Kanazawa Y, Abdel-Wanis M, et al. Effect of timing of pulmonary metastases identification on prognosis of pateints with osteosarcoma: the Japanese musculoskeletal oncology group study. J Clin Oncol. 2002;20:3470-3477.
Barney JD, Churchill EJ. Adenocarcinoma of the kidney with metastasis to the lung cured by nephrectomy and lobectomy. J Urol. 1939;42:269-276.
Ochsner A, Clemmons E, Mitchell W. Treatment of metastatic pulmonary malignant lesions. J Lancet. 1963;83:16-24.
Thomford N, Woolner L, Clagett O. The surgical treatment of metastatic tumors in lungs. J Thorac Cardiovasc Surg. 1963;49:357-363.
Richardson WR. Progress in pediatric cancer surgery. Arch Surg. 1961;82:641-655.
Martini N, Huvos AG, Mike V, et al. Multiple pulmonary resections in the treatment of osteogenic sarcoma. Ann Thorac Surg. 1971;12:271-280.
Beattie EJ, Harvey JC, Marcove R, et al. Results of multiple pulmonary resections for metastatic osteogenic sarcoma after two decades. J Surg Oncol. 1991;46:154-155.
Virgo KS, Naunheim KS, Johnson FE. Preoperative workup and postoperative surveillance for patients undergoing pulmonary metastasectomy. Thorac Surg Clin. 2006;16:125-131.
Aquino SL, Kuester LB, Muse VV, et al. Accuracy of transmission CT and FDG-PET in the detection of small pulmonary nodules with integrated PET/CT. Eur J Nucl Med Mol Imaging. 2006;33:692-696.
Pastorino U, Buyse M, Friedel G, et al. Long-term results of lung metastasectomy: prognostic analyses based on 5206 cases. J Thorac Cardiovasc Surg. 1997;113:37-49.
Temeck BK, Wexler LH, Steinberg SM, et al. Metastasectomy for sarcomatous pediatric histologies – results and prognostic factors. Ann Thorac Surg. 1995;59:1385-1390.
Suzuki M, Iwata T, Ando S, et al. Predictors of long-term survival with pulmonary metastasectomy for osteosarcomas and soft tissue sarcomas. J Cardiovasc Surg. 2006;47:603-608.
Rusch VW. Pulmonary metastasectomy. Current indications (Review). Chest. 1995;107:322s-331s.
Lanza LA, Putnam JB Jr. Resection of pulmonary metastases. In: Roth JA, Ruckdeschel JR, Weisenberger TH, eds. Thoracic Oncology. 2nd ed. Philadelphia: W.B. Saunders; 1996:569-589.
Putnam JB Jr, Roth JA. Secondary tumors in the lungs. In: Shields TW, ed. General Thoracic Surgery. 4th ed. Philadelphia: Williams & Wilkins; 1994:1334-1352.
Younes RN, Gross JL, Deheinzelin D. Surgical resection of unilateral lung metastases: is bilateral thoracotomy necessary? World J Surg. 2002;26:1112-1116.
Kayton ML, Huvos AG, Casher J, et al. Computed tomographic scan of the chest underestimates the number of metastatic lesions in osteosarcoma. J Pediatr Surg. 2006;41:200-204.
Parsons AM, Detterbeck FC, Parker LA. Accuracy of helical CT in the detection of pulmonary metastases: is intraoperative palpation still necessary? Ann of Thorac Surg. 2004;78:1910-1916.
Castagnetti M, Delarue A, Gentet JC. Optimizing the surgical management of lung nodules in children with osteosarcoma – thoracoscopy for biopsies, thoracotomy for resections. Surg Endosc. 2004;18:1668-1671.
Sartorelli KH, Partrick D, Meagher DP. Port-site recurrence after thoracoscopic resection of pulmonary metastasis owing to osteogenic sarcoma. J Pediatr Surg. 1996;31:1443-1444.
Walsh GL, Nesbitt JC. Tumor implants after thoracoscopic resection of a metastatic sarcoma. Ann Thorac Surg. 1995;59:215-216.
Mack MJ, Gordon MJ, Postma TW, et al. Percutaneous localization of pulmonary nodules for thoracoscopic lung resection. Ann Thorac Surg. 1992;53:1123-1124.
Chella A, Lucchi M, Ambrogi MC, et al. A pilot study of the role of TC-99 radionuclide in localization of pulmonary nodular lesions for thoracoscopic resection. Eur J Cardiothorac Surg. 2000;18:17-21.
Moon SW, Wang YP, Jo KH, et al. Fluoroscopy-aided thoracoscopic resection of pulmonary nodule localized with contrast media. Ann Thorac Surg. 1999;68:1815-1820.
Parsons AM, Ennis EK, Yankaskas BC, et al. Helical computed tomography inaccuracy in the detection of pulmonary metastases: can it be improved? Ann Thorac Surg. 2007;84:1830-1837.
McCormack PM, Bains MS, Begg CB, et al. Role of video-assisted thoracic surgery in the treatment of pulmonary metastases: results of a prospective trial. Ann Thorac Surg. 1996;62:213-216.
Mineo TC, Ambrogi V, Paci M, et al. Transxiphoid bilateral palpation in video-assisted thoracoscopic lung metastasectomy. Arch Surg. 2001;136:783-788.
Putnam JB, Suell DM, Natarajan G, et al. Extended resection of pulmonary metastases – is the risk justified. Ann Thorac Surg. 1993;55:1440-1446.
Veronesi G, Petrella F, Leo F, et al. Prognostic role of lymph node involvement in lung metastasectomy. J Thorac Cardiovasc Surg. 2007;133:967-972.
Dominguez-Ventura A, Nichols F. Lymphadenectomy in metastasectomy. Thorac Surg Clin. 2006;16:139-143.
Pfannschmidt J, Mode J, Muley T, et al. Nodal involvement at the time of pulmonary metastasectomy: experiences in 245 patients. Ann Thorac Surg. 2006;81:448-454.
Ghaye B, Bruyere PJ, Dondelinger RF. Nonfatal systemic air embolism during percutaneous radiofrequency ablation of a pulmonary metastasis. AJR Am J Roentgenol. 2006;187:W327-W328.
Koong HN, Pastorino U, Ginsberg RJ. Is there a role for pneumonectomy in pulmonary metastases? Ann Thorac Surg. 1999;68:2039-2043.
Vaporciyan AA, Rice D, Correa AM, et al. Resection of advanced thoracic malignancies requiring cardiopulmonary bypass. Eur J Cardiothorac Surg. 2002;22:47-52.
Ying C, Gang S. Successful resection of osteosarcoma pulmonary metastasis extending into left side of heart under cardiopulmonary bypass: a case report. Chin Med J. 2002;115(11):1743-1744.
Kandioler D, Kromer E, Tuchler H, et al. Long-term results after repeated surgical removal of pulmonary metastases. Ann Thorac Surg. 1998;65:909-912.
Temeck BK, Wexler LH, Steinberg SM, et al. Reoperative pulmonary metastasectomy for sarcomatous pediatric histologies. Ann Thorac Surg. 1998;66:908-912.
Briccoli A, Rocca M, Salone M, et al. Resection of recurrent pulmonary metastases in patients with osteosarcoma. Cancer. 2005;104:1721-1725.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2009 Springer Science+Business Media, LLC
About this chapter
Cite this chapter
Steliga, M., Vaporciyan, A. (2009). Surgical Treatment of Pulmonary Metastases from Osteosarcoma in Pediatric and Adolescent Patients. In: Jaffe, N., Bruland, O., Bielack, S. (eds) Pediatric and Adolescent Osteosarcoma. Cancer Treatment and Research, vol 152. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-0284-9_9
Download citation
DOI: https://doi.org/10.1007/978-1-4419-0284-9_9
Published:
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4419-0283-2
Online ISBN: 978-1-4419-0284-9
eBook Packages: MedicineMedicine (R0)