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Strategies to Overcome Efflux Pumps

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Oral Delivery of Macromolecular Drugs

Abstract

Intestinal efflux pumps such as P-glycoprotein play a significant role in altering the absorption of a wide range of drugs. Anticancer agents, antibiotics, antivirals, calcium channel blockers, immunosuppressive agents, peptide drugs and several other therapeutic compounds have been reported to be substrates of one or more transmembrane efflux transporters.

Inhibition of these efflux pumps by various compounds can lead to enhanced absorption of several drugs across the intestine.

In this chapter, several efflux pump inhibitors such as low molecular mass inhibitors, polymeric inhibitors and advanced formulation approaches on how to overcome drug efflux are discussed.

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Authors and Affiliations

  1. Diabetes Research Unit, Oral Formulation Research, Novo Nordisk A/S, Målφv, Denmark

    Florian Föger

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  1. Florian Föger
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Correspondence to Florian Föger .

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Editors and Affiliations

  1. Naturwissenschaftliche Fakultät, Universität Innsbruck, Innrain 52, Innsbruck, 6020, Austria

    Andreas Bernkop-Schnürch

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Föger, F. (2009). Strategies to Overcome Efflux Pumps. In: Bernkop-Schnürch, A. (eds) Oral Delivery of Macromolecular Drugs. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-0200-9_7

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