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Risks Involved in the Use of Herbal Products

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Abstract

The use of different herbal products can involve several kinds of risks that include improper labeling or failure to provide the correct constituents; inadequate testing of the herbal product in clinical trials; failure to provide the stated amounts of active constituents; contraindications between known herbs and synthetic prescription drugs used to treat the same disease; overdosing or underdosing; contamination of herbal preparations with pathogens, pesticides, and heavy metals; expired shelf life; and problems with formulations that render them ineffective (e.g., ineffective dried preps in capsules versus effective formulations taken as tinctures). In this chapter, we shall address many of these issues. They are basically issues of quality control that involve the latest advances in plantbiotechnology.

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References

  • Brambilla, A., Lo Scalzo, R., Bertolo, G., Torreggiani, D. 2008. Steam-blanched highbush blueberry (Vaccinium corymbosum L.) juice: phenolic profile and antioxidant capacity in relation to cultivar selection. J Agric Food Chem 56: 2643–2648.

    Article  PubMed  CAS  Google Scholar 

  • Burdulis, D., Ivanauskas, L., Jakstas, V., Janulis, V. 2007. Analysis of anthocyanin content in bilberry (Vaccinium myrtillus L.) fruit crude drugs by high-performance liquid chromatography method. Medicina (Kaunas) 43: 568–574.

    Google Scholar 

  • Cao, G., Prior, R.L. 1998. Comparison of different analytical methods for assessing total antioxidant capacity of human serum. Clin Chem 44: 1309–1315.

    PubMed  CAS  Google Scholar 

  • Cassinese, C., de Combarieu, E., Falzoni, M., Fuzzati, N., Pace, R., Sardone, N. 2007. New liquid chromatography method with ultraviolet detection for analysis of anthocyanins and anthocyanidins in Vaccinium myrtillus fruit dry extracts and commercial preparations. J AOAC Int 90: 911–919.

    PubMed  CAS  Google Scholar 

  • Connor, A.M., Luby, J.J., Hancock, J.F., Berkheimer, S., Hanson, E.J. 2002. Changes in fruit antioxidant activity among blueberry cultivars during cold-temperature storage. J Agric Food Chem 50: 893–898.

    Article  PubMed  CAS  Google Scholar 

  • Dekosky, S.T, Williamson, J.D., Fitzpatrick, A.L., Kronmal, R.A., Ives, D.G., Saxton, J.A., Lopez, O.L., Burke, G., Carlson, M.C., Fried, L.P., Kuller, L.H., Robbins, J.A., Tracy, R.P., Woolard, N.F., Dunn, L., Snitz, B.E., Nahin, R.L., Furberg, C.D.; for the Ginkgo Evaluation of Memory (GEM) Study Investigators. 2008. Ginkgo biloba for prevention of dementia: a randomized controlled trial. JAMA 300: 2253–2262.

    Google Scholar 

  • Dugoua, J.J., Seely, D., Perri, D., Mills, E., Koren, G. 2008. Safety and efficacy of cranberry (Vaccinium macrocarpon) during pregnancy and lactation. Can J Clin Pharmacol 15: e80–86.

    PubMed  Google Scholar 

  • Galati, G., O’Brien, P.J. 2004. Potential toxicity of flavonoids and other dietary phenolics: significance for their chemopreventive and anticancer properties. Free Radic Biol Med 3: 287–303.

    Article  Google Scholar 

  • Grant, D.C., Helleur, R.J. 2008. Rapid screening of anthocyanins in berry samples by surfactant-mediated matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Rapid Commun Mass Spectrom 22: 156–164.

    Article  PubMed  CAS  Google Scholar 

  • Gruenwald, J., Brendler, T., Jaenicke, C. (editors) 2007. Physicians Desk Reference (PDR) for Herbal Medicines. 4th edition, pp. 1–1026. Physicians Desk Reference, Inc.

    Google Scholar 

  • Gunes, G., Liu, R.H., Watkins, C.B. 2002. Controlled-atmosphere effects on postharvest quality and antioxidant activity of cranberry fruits. J Agric Food Chem 50: 5932–5938.

    Article  PubMed  CAS  Google Scholar 

  • Harris, C.S., Burt, A.J., Saleem, A., Le, P.M., Martineau, L.C., Haddad, P.S., Bennett, S.A., Arnason, J.T. 2007. A single HPLC-PAD-APCI/MS method for the quantitative comparison of phenolic compounds found in leaf, stem, root and fruit extracts of Vaccinium angustifolium. Phytochem Anal 18: 161–169.

    Article  PubMed  CAS  Google Scholar 

  • Kalt, W., Forney, C.F., Martin, A., Prior, R.L. 1999. Antioxidant capacity, vitamin C, phenolics, and anthocyanins after fresh storage of small fruits. J Agric Food Chem 47: 4638–4644.

    Article  PubMed  CAS  Google Scholar 

  • Krenn, L., Steitz, M., Schlicht. C., Kurth, H., Gaedcke, F. 2007. Anthocyanin- and proanthocyanidin-rich extracts of berries in food supplements–analysis with problems. Pharmazie 62: 803–812.

    PubMed  CAS  Google Scholar 

  • Lin, L.Z., Harnly, J.M. 2007. A screening method for the identification of glycosylated flavonoids and other phenolic compounds using a standard analytical approach for all plant materials. J Agric Food Chem 55: 1084–1096.

    Article  PubMed  CAS  Google Scholar 

  • Lohachoompol, V., Srzednicki, G., Craske, J. 2004. The change of total anthocyanins in blueberries and their antioxidant effect after drying and freezing. J Biomed Biotechnol. 2004: 248–252.

    Article  PubMed  Google Scholar 

  • Lyons, M.M., Yu, C., Toma, R.B., Cho, S.Y., Reiboldt, W., Le, J., van Breemen, R.B. 2003. Resveratrol in raw and baked blueberries and bilberries. J Agric Food Chem 51: 5867–5870.

    Article  PubMed  CAS  Google Scholar 

  • Määttä-Riihinen, K.R., Kamal-Eldin, A., Mattila, P.H., González-Paramás, A.M., Törrönen, A.R. 2004. Distribution and contents of phenolic compounds in eighteen Scandinavian berry species. J Agric Food Chem 52: 4477–4486.

    Article  PubMed  Google Scholar 

  • Manach, C., Williamson, G., Morand, C., Scalbert, A., Rémésy, C. 2005. Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies. Am J Clin Nutr 81: 230S–242S.

    PubMed  CAS  Google Scholar 

  • Mathews, J.M., Etheridge, A.S., Black, S.R. 2002. Inhibition of Human Cytochrome P450 Activities by Kava Extract and Kavalactones. Drug Metab Dispos 30: 1153–1157.

    Article  PubMed  CAS  Google Scholar 

  • Moore, M. 1995. Herbal materia medica, 5th edition, S.W. School of Botanical Medicine, P.O. Box 4565, Bisbee, AZ.

    Google Scholar 

  • Nichenametla, S.N., Taruscio, T.G., Barney, D.L., Exon, J.H. 2006. A review of the effects and mechanisms of polyphenolics in cancer. Crit Rev Food Sci Nutr 46: 161–183.

    Article  PubMed  CAS  Google Scholar 

  • Ody, P. 1993. The Complete Medicinal Herbal: A practical guide to the healing properties of herbs, with more than 250 remedies for common ailments. Dorling Kindersley™ Limited, London, WC2R U.K.

    Google Scholar 

  • Prior, R.L., Cao, G. 2000. Analysis of botanicals and dietary supplements for antioxidant capacity: a review. J AOAC Int. 83: 950–956.

    PubMed  CAS  Google Scholar 

  • Prior, R.L., Cao, G. 1999. In vivo total antioxidant capacity: comparison of different analytical methods. Free Radic Biol Med. 27: 1173–1181.

    Article  PubMed  CAS  Google Scholar 

  • Puupponen-Pimiä, R., Nohynck L., Ammann, S., Oksman-Caldentey, K.M., Buchert, J. 2008. Enzyme-assisted processing increases antimicrobial and antioxidant activity of bilberry. J Agric Food Chem 56: 681–688.

    Article  PubMed  Google Scholar 

  • Rodeiro, I., Donato M.T., Lahoz, A., Garrido, G., Delgado, R., Gómez-Lechón, M.J. 2008. Interactions of polyphenols with the P450 system: possible implications on human therapeutics. Mini Rev Med Chem 8: 97–106.

    Article  PubMed  CAS  Google Scholar 

  • Seeram, N.P., Aviram, M., Zhang, Y., Henning, S.M., Feng, L., Dreher, M., Heber, D. 2008. Comparison of antioxidant potency of commonly consumed polyphenol-rich beverages in the United States. J Agric Food Chem 56: 1415–1422.

    Article  PubMed  CAS  Google Scholar 

  • Shekelle, P, Morton, S.C., Maglione, M., Hardy, M., Suttorp, M., Roth, E., Jungvig, L., Mojica, W., Gagné, J., Rhodes, S., McKinnon, E., Newberry, S. 2003a. Ephedra and ephedrine for weight loss and athletic performance enhancement: clinical efficacy and side effects. Prepared for the Agency for Healthcare Research and Quality. Full text available at www.ahrq.gov/clinic/ephedinv.htm.

  • Shekelle P., Hardy, M., Morton, S.C., Maglione, M., Mojica, W., Suttorp, M., Rhodes, S., Jungvig, L., Gagné, J. 2003b. Efficacy and safety of ephedra and ephedrine for weight loss and athletic performance: a meta-analysis. JAMA 289: 537–545.

    Article  Google Scholar 

  • Skibola, C.F., Smith, M.T. 2000. Potential health impacts of excessive flavonoid intake. Free Radic Biol Med 29: 375–383.

    Article  PubMed  CAS  Google Scholar 

  • Song, G.Q., Sink, K.C. 2006. Blueberry (Vaccinium corymbosum L.). Methods Mol Biol 344:263–272.

    PubMed  CAS  Google Scholar 

  • Srivastava , A., Akoh, C.C., Yi, W., Fischer, J., Krewer, G. 2007. Effect of storage conditions on the biological activity of phenolic compounds of blueberry extract packed in glass bottles. J Agric Food Chem 55: 2705–2713.

    Article  PubMed  CAS  Google Scholar 

  • Tian, Q., Giusti, M.M., Stoner, G.D., Schwartz, S.J. 2005. Screening for anthocyanins using high-performance liquid chromatography coupled to electrospray ionization tandem mass spectrometry with precursor-ion analysis, product-ion analysis, common-neutral-loss analysis, and selected reaction monitoring. J Chromatogr A 109: 72–82.

    Article  Google Scholar 

  • Vattem, D.A., Ghaedian, R., Shetty, K. 2005. Enhancing health benefits of berries through phenolic antioxidant enrichment: focus on cranberry. Asia Pac J Clin Nutr 14: 120–130.

    PubMed  CAS  Google Scholar 

  • Vinson, J.A., Bose, P., Proch, J., Al Kharrat, H., Samman, N. 2008. Cranberries and cranberry products: powerful in vitro, ex vivo, and in vivo sources of antioxidants. J Agric Food Chem 56: 5884–5891.

    Article  PubMed  CAS  Google Scholar 

  • Wang, C.Y., Wang, S.Y., Chen, C. 2008. Increasing antioxidant activity and reducing decay of blueberries by essential oils. J Agric Food Chem 56: 3587–3592.

    Article  PubMed  CAS  Google Scholar 

  • Wang, L.S., Stoner, G.D., 2008. Anthocyanins and their role in cancer prevention. Cancer Lett 269: 281–290.

    Article  PubMed  CAS  Google Scholar 

  • Wang, S.Y., Stretch, A.W. 2002. Antioxidant capacity in cranberry is influenced by cultivar and storage temperature. J Agric Food Chem 49: 969–974.

    Article  Google Scholar 

  • Williamson, G., Manach, C. 2005. Bioavailability and bioefficacy of polyphenols in humans II. Review of 93 intervention studies. Am J Clin Nutr 81: 243S–255S.

    PubMed  CAS  Google Scholar 

  • Zhang, Z., Kou, X., Fugal, K., McLaughlin, J. 2004. Comparison of HPLC methods for determination of anthocyanins and anthocyanidins in bilberry extracts. J Agric Food Chem 52: 688--691.

    Google Scholar 

  • Zheng, Y., Wang, C.Y., Wang, S.Y., Zheng, W. 2003. Effect of high-oxygen atmospheres on blueberry phenolics, anthocyanins, and antioxidant capacity. J Agric Food Chem 51: 7162–7169.

    Article  PubMed  CAS  Google Scholar 

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Correspondence to Peter B. Kaufman .

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Kaufman, P.B., McKenzie, M., Kirakosyan, A. (2009). Risks Involved in the Use of Herbal Products. In: Recent Advances in Plant Biotechnology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-0194-1_14

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