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Targeting Toll-Like Receptor for the Induction of Immune and Antitumor Responses

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Targeted Cancer Immune Therapy

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Abstract

A very unique and important feature of TLR (toll-like receptor) agonists is their ability to modulate TLR on the cells of the innate immune system resulting in changes that will induce effective and efficient adaptive immune responses. Therefore, stimulation of TLR pathways through their respective ligands presents a potentially attractive approach to activate adaptive anticancer immune responses. In this chapter, we summarize the effect of targeting some of the TLR for the induction of antitumor responses. Although the use of TLR agonists as future vaccine adjuvants seems very promising, we also need to proceed with caution and long term studies will be critical in assessing the propensity of chronic therapy to trigger autoimmune conditions or promote tumor growth.

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Authors and Affiliations

  1. Cancer Center Scottsdale, Mayo Clinic Arizona, 13400 East Shea Boulevard Scottsdale, AZ, 85259, USA

    Joseph Lustgarten

Authors
  1. Joseph Lustgarten
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  2. Dominique Hoelzinger
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  3. Maria Adelaida Duque
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  4. Shannon Smith
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  5. Noweeda Mirza
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Correspondence to Joseph Lustgarten .

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Editors and Affiliations

  1. Sidney Kimmel Cancer Center, Altman Row 10835, San Diego, 92121, U.S.A.

    Joseph Lustgarten

  2. Health Sciences Center, Louisiana State University, Bolivar Street 533, New Orleans, 70112, U.S.A.

    Yan Cui

  3. School of Veterinary Medicine, Louisiana State University, Skip Bertman Drive, Baton Rouge, 70803, U.S.A.

    Shulin Li

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Lustgarten, J., Hoelzinger, D., Duque, M.A., Smith, S., Mirza, N. (2009). Targeting Toll-Like Receptor for the Induction of Immune and Antitumor Responses. In: Lustgarten, J., Cui, Y., Li, S. (eds) Targeted Cancer Immune Therapy. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-0170-5_17

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