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Animal Imaging

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Imaging in CNS Drug Discovery and Development

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Abstract

This chapter discusses challenges and practical approaches to animal fMRI with respect to anesthetic regimens, conscious animal studies, activation paradigms, optimal pulse sequence selection, and the rigor required for drug discovery applications. Examples on the use of animal fMRI to support drug discovery are presented. The examples illustrate (1) technical development and qualification of a quantitative assay for pain, (2) the use of pharmacological tools to support a link between a receptor antagonist elicited ASL-CBF change with the corresponding neuronal activity, and (3) interrogation of mechanism of action of an analgesic.

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Acknowledgments

We acknowledge the contributions of Denise Welsh to the unpublished data presented here. We thank Jeffery Evelhoch and Richard Hargreaves for their valuable input.

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Authors and Affiliations

  1. Imaging Department, Merck Research Laboratories, West Point, Pennsylvania, USA

    Donald Williams

Authors
  1. Donald Williams
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  2. Alexandre Coimbra
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  3. Fuqiang Zhao
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Corresponding author

Correspondence to Donald Williams .

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Editors and Affiliations

  1. Mill Street 115, Belmont, 02478, U.S.A.

    David Borsook

  2. Mill Street 115, Belmont, 02478, U.S.A.

    Lino R. Beccera

  3. Dept. Psychiatry, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 2QQ, United Kingdom

    Edward Bullmore

  4. Sumneytown Pike , West Point, 19486, U.S.A.

    Richard J. Hargreaves

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Williams, D., Coimbra, A., Zhao, F. (2010). Animal Imaging. In: Borsook, D., Beccera, L., Bullmore, E., Hargreaves, R. (eds) Imaging in CNS Drug Discovery and Development. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-0134-7_9

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