Abstract
The field of drug development and discovery encounters a number of challenges in identifying effective therapeutics to treat central nervous system (CNS) diseases. Experimental methods such as pharmacokinetic/pharmacodynamic (PK/PD) modeling and behavioral testing have been the conventional means to assess drug efficacy. Here we introduce functional Magnetic Resonance Imaging (fMRI) as a complimentary technique that can be implemented to assess the effectiveness of a therapeutic in CNS disease. FMRI has the unique ability to characterize the de novo drug effect on specific CNS targets, as is done in Positron Emission Tomography, as well as determine how neuronal substrates or networks are influenced by the therapeutic of interest during sensory stimulation or cognitive and motor tasks. Furthermore, fMRI measures can easily be related to the results obtained from conventional standards, such as PK/PD modeling. FMRI is believed to be a promising experimental method that can assist in defining drug effect in early stages of drug development and discovery; and thus, improve the go-no-go decision-making process of newly identified drugs to treat CNS disease.
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Upadhyay, J., Borsook, D., Becerra, L. (2010). Functional Magnetic Resonance Imaging in Drug Development. In: Borsook, D., Beccera, L., Bullmore, E., Hargreaves, R. (eds) Imaging in CNS Drug Discovery and Development. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-0134-7_5
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