Integrative Processes: Neuroscience Clinical Imaging Biomarkers

Chapter

Abstract

The promise of neuroimaging to speed up the discovery of drugs and the development in the neurosciences is high and there is considerable enthusiasm for the wide-spread implementation of many techniques. However, there is a need to balance advocacy with objectivity as we test the decision making value of differing imaging approaches and choose which to integrate into our routine discovery processes. Today the most commonly used are Positron Emission Tomography (PET) often with novel target-specific tracers, and functional magnetic resonance imaging (fMRI). These neuroimaging technologies can be scientifically validated and clinically qualified for use in preclinical investigations and clinical studies in healthy volunteers and patients to assess the efficacy of novel targets, pick the best molecules, and provide estimates of target engagement, dose response and pharmacodynamic effects of drugs within the brain. Neuroimaging has the potential to shorten the development cycle and help bring safe and effective medicines for neurological and psychiatric disorders faster to those who need them.

Keywords

Placebo Depression Dopamine Serotonin Radionuclide 

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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Schering-Plough, IncKenilworthUSA

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