Translational MRI in CNS Drug Discovery
Translational neuroimaging has the potential to create a more successful link between preclinical and clinical research, thereby improving the predictivity of animal models and the development of innovative therapeutics. In this review, the emphasis is on “back translation”: how can clinical imaging data be best utilized to enhance preclinical drug discovery programs? Examples selected in the fields of Alzheimer’s disease and Schizophrenia elucidate the great potential – as well as some pitfalls – of translational MRI in CNS drug discovery.
KeywordsSchizophrenic Patient Blood Oxygenation Level Dependent Translational Medicine Total Brain Volume Diffusion Tensor Magnetic Resonance Imaging
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