Liver Cancer pp 489-497 | Cite as

Splenic Metastases: Diagnostic Methods

  • Eva Compérat
  • Frédéric Charlotte
Part of the Methods of Cancer Diagnosis, Therapy and Prognosis book series (HAYAT, volume 5)

Metastases from solid tumors to the spleen due to hematogenous dissemination are confined to the splenic parenchyma, and should not be confused with small superficial subcapsular foci associated with peritoneal dissemination observed in ovarian cancers (Tserkezoglou et al., 2005). According to this definition, splenic metastases were thought to be excep tional but the incidence of reported cases has been increasing due to the improvement of medical imaging and the long-term follow-up of patients with cancer. Metastases to the spleen generally occur in the context of mul-tivisceral metastatic cancer at terminal stage. Solitary metastases have also been reported (Compérat et al., 2007), and are becoming a diagnostic dilemma with primary tumors of the spleen. After a brief description of epi demiology, pathologic features, pathogenesis and clinical aspects of splenic metastases, this review will outline diagnostic procedures and the differential diagnoses.


Mantle Cell Lymphoma Uveal Malignant Melanoma Hairy Cell Leukemia Skin Melanoma Splenic Lesion 
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Copyright information

© Springer Science + Business Media B.V. 2009

Authors and Affiliations

  • Eva Compérat
    • 1
  • Frédéric Charlotte
    • 1
  1. 1.Service d'Anatomie PathologieGH La Pitié-Salpetrière, Boulevard de l'hôpitalParisFrance

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