Extrahepatic Bile Duct Carcinoma: Mucin 4, a Poor Prognostic Factor
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Malignant tumors of the extrahepatic bile ducts are relatively rare, although they are one of the most common causes of extrahepatic bile duct obstruction. Most tumors of extrahepatic bile ducts are car cinomas, and they can develop at any level of bile duct tree. Extrahepatic bile duct carcinoma (EHBDC) is difficult to treat because most patients with this car cinoma are not surgically resectable at the time of diagnosis despite its small size. A gradual improvement with better prog nosis has been obtained with a combined modality approach consisting of surgery, radiation therapy, and chemotherapy, but survival rate is still low. A complete surgi cal resection offers the only possibility of cure; however, many patients treated with curative resection have a poor outcome. Our previous immunohistochemical stud ies of EHBDC showed that MUC4 mucin expression is a new independent factor for poor prognosis and predicts the outcome of patients with EHBDC (Tamada et al., 2006), in addition to MUC1 mucin expres sion (Tamada et al., 2002).
KeywordsBile Duct Common Bile Duct Extrahepatic Bile Duct ErbB2 Expression MUC4 Expression
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