Liver Cancer pp 325-331 | Cite as

Hepatocellular Carcinoma: KiSS-1 Overexpression as a Prognostic Factor

  • Katharina Schmid
  • Isabella Mosberger
  • Fritz Wrba
Part of the Methods of Cancer Diagnosis, Therapy and Prognosis book series (HAYAT, volume 5)

Knowing about reliable prognostic markers is of great clinical importance to predict relapse and dissemination of hepatocellular carcinoma (HCC), one of the most common malignant diseases worldwide. It is well known that surgery serves as the only curative therapy; by the end of the last century, orthotopic liver transplantation had become an optional treatment for a subgroup of patients with low tumor stage, resulting in better prognosis with regard to tumor recurrence (Island et al., 2005).

Lee et al. (1996) reported for the first time that the KiSS-1 gene, mapped to chromosome 1q32–q41, functions as a metastasis suppressor gene. This working group found that KiSS-1 mRNA expression occurred only in nonmetastatic, but not in metastatic melanoma. Lee and Welch (1997) also observed that the expression of KiSS-1 reduced the metastatic potential of human breast carcinoma cells by 95%, while tumorigenicity was not affected.


Primary Biliary Cirrhosis Orthotopic Liver Transplantation Human Breast Carcinoma Cell Metastasis Suppressor Gene Antiestrogenic Therapy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science + Business Media B.V. 2009

Authors and Affiliations

  • Katharina Schmid
    • 1
  • Isabella Mosberger
    • 1
  • Fritz Wrba
    • 1
  1. 1.Department of Clinical PathologyMedical University of ViennaViennaAustria

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