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Liver Cancer pp 303-310 | Cite as

Postoperative Interferon Alpha Treatment of Patients with Hepatocellular Carcinoma: Expression of p48 Using Tissue Microarray

  • Hui-Chuan Sun
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Part of the Methods of Cancer Diagnosis, Therapy and Prognosis book series (HAYAT, volume 5)

Hepatocellular carcinoma (HCC) is a major health problem in China and the third most common cause of cancer death in the world (Parkin et al., 2005). Surgical resection can have a curative outcome, but > 50% of patients will have recurrence in the first 5 years after resection (Poon, 2007), and the recurrence usually results in death (Regimbeau et al., 2004). No standard postoperative adjuvant therapy has yet been established (Sun and Tang, 2003).

In a previous study, we demonstrated that interferon-α (IFN-α) delays tumor growth and inhibits metastasis in a nude mouse model (Wang et al., 2000). Further studies revealed that both antiangio-genesis and antiproliferative effects are involved in the antitumor effect in the HCC model (Wang et al., 2003; Wu et al., 2004, 2005). In addition to the direct antitumor effect, the antivirus effect may also be involved in the prevention of recurrence of HCC. Some reports have indicated that long-term IFN-α reduces the incidence of HCC in patients with chronic hepatitis B virus (HBV) or hepatitis C virus (HCV) infection (Lin et al., 2007; Y u et al., 2006).

Keywords

Hepatocellular Carcinoma Tissue Microarray Lular Carcinoma Tissue Microarray Analysis HBeAg Positive Chronic Hepatitis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science + Business Media B.V. 2009

Authors and Affiliations

  • Hui-Chuan Sun
    • 1
  1. 1.Liver Cancer Institute and Zhongshan HospitalFudan UniversityShanghaiChina

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