Liver Cancer pp 287-301 | Cite as

Perfusion Scintigraphy with Integrated Single Photon Emission Computed Tomography/Computed Tomography in the Management of Transarterial Treatment of Hepatic Malignancies

  • Timm Denecke
  • Bert Hildebrandt
  • Enrique Lopez-Hänninen
Part of the Methods of Cancer Diagnosis, Therapy and Prognosis book series (HAYAT, volume 5)

During the recent years it has been shown that transarterial applications of anticancer agents are promising approaches in the treatment of hepatic malignancies. While new techniques led to a reappraisal of hepatic arterial infusion chemotherapy (HAIC) over implanted port systems, there has also been a growing interest in the use of transarterial radioembolization (RE). The concept of transarterial regional oncologic treatment of hepatic malignancies presupposes that the entire liver can be exclusively treated over the supplying arteries. Several imaging modalities are in use for prediction and control of per-fusion territories of intraarterial catheters. Besides digital subtraction angiography (DSA), computed tomography (CT) and magnetic resonance imaging (MRI), scin-tigraphic imaging is being employed to visualize the intrahepatic perfusion pattern, to exclude extrahepatic perfusion, and to assess an intrahepatic arteriovenous shunting to the lung. In the following, the current status of HAIC and RE in cancer therapy, the application techniques and the use of different imaging modalities, especially single photon emission computed tomography (SPECT) and SPECT with integrated computed tomography (SPECT-CT), for planning and control of treatment will be discussed.


Hepatic Artery Digital Subtraction Angiography Port System Hepatic Arterial Infusion Chemotherapy Hepatic Malignancy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science + Business Media B.V. 2009

Authors and Affiliations

  • Timm Denecke
    • 1
  • Bert Hildebrandt
    • 1
  • Enrique Lopez-Hänninen
    • 1
  1. 1.Campus Virchow-KlinikumCharite-Universitatmedizin Berlin, Klinik fur Strahlenheilkonde und PET Zentrum BerlinBerlinGermany

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