Hepatocellular Carcinoma: Effect of Injection Rate/Injection Duration of Contrast Material on Computed Tomography
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Multiphasic, contrast-enhanced computed tomography (CT) scanning has improved the detection and characterization of focal hepatic lesions, such as hepatocellular carcinomas (HCC) (Ohashi et al., 1993; Hollett et al., 1995; Baron et al., 1996). It has been well established that hepatic arterial-dominant phase (HAP) scanning is essential to detect hypervascular HCC. Hepatic arterial-dominant phase images can detect a larger number of HCC (67/81, 83%) than any other phases including unenhanced, portal venous phase (PVP), and delayed phase (DP) images (Hwang et al., 1997). In addition, some hypervas-cular HCC (26–32%) are only seen or are most conspicuous on HAP images (Hwang et al., 1997; Mitsuzaki et al., 1996).
The injection rate of the contrast material is one of the most important technique-related factors for detecting hypervascular HCC on HAP images. The enhancement of the aorta (including hepatic artery) on HAP images significantly increases at higher injection rates of contrast material (Tublin et al., 1999; Kim et al., 1998). Based on these results, it was suggested that higher injection rates of contrast material can improve hypervascular hepatic lesion detection (Kim et al., 1995).
KeywordsInjection Rate Helical Compute Tomography Cirrhotic Liver Injection Protocol Injection Duration
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