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Liver Cancer pp 193-211 | Cite as

Expression of Vascular Endothelial Growth Factor in Hepatocellular Carcinoma: Correlation with Radiologic Findings

  • Masayuki Kanematsu
  • Richard C. Semelka
  • Shinji Osada
Chapter
  • 1.7k Downloads
Part of the Methods of Cancer Diagnosis, Therapy and Prognosis book series (HAYAT, volume 5)

Angiogenesis is the process whereby new blood vessels develop from the preexisting vasculature. It takes place physiologically during embryonic development, during the normal growth of tissues and the wound healing, and during the female reproductive cycle (i.e., ovulation, menstruation, and placental development) as well as during the pathologic growth and metastatic spread of malignant neoplasms (Folkman, 1971). A variety of humoral agents need to be activated to generate a neovascular blood supply or angiogenesis in the human body, and vascular endothelial growth factor (VEGF) is one of the most important humoral agents to be activated to ensure the growth of the vascular endothelium.

Various types of hepatocellular nodules with malignant potential are known to develop in livers with chronic liver damage: they are large regenerative nodules, low-grade dysplastic nodules, high-grade dysplastic nodules, well-differentiated hepatocellular carcinoma (HCC), and moderately or poorly differentiated HCC (International Working Party, 1995). In the process of HCC development, the expression of proangiogenetic factors such as VEGF appears to play an important role. The expression of this factor in HCC tissues has been considered to be associated with tumor size or histological tumor grade (Yamaguchi et al., 1998). Even in the nontumorous liver parenchyma, VEGF is expressed by sinusoidal endothelial cells and hepatocytes (Yamane et al., 1994).

Keywords

Dysplastic Nodule Hepatic Nodule Surrounding Liver Arterial Portography Hepatocellular Nodule 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science + Business Media B.V. 2009

Authors and Affiliations

  • Masayuki Kanematsu
    • 1
  • Richard C. Semelka
    • 1
  • Shinji Osada
    • 1
  1. 1.Department of Radiology ServicesGifu University HospitalGifuJapan

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