Hepatocellular Carcinoma: Magnetic Resonance Imaging
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Hepatocellular carcinoma (HCC) is the most common primary hepatic malignancy, accounting for 90% of primary liver neoplasms and is responsible for up to 1 million deaths annually worldwide (Fung and Marsh, 2002). The major risk factor for HCC is cirrhosis. All types of cirrhoses predispose to HCC, but the incidence is particularly high in patients with chronic hepatitis B (HBV), chronic hepatitis C (HCV), and in alcoholic liver disease. HCC develops by sequential steps from low grade dysplastic nodules to frank malignant HCC. The recognition of HCC is critical because curative treatment (including surgical resection and liver transplantation) and prognosis depend on early diagnosis. The 5-year survival rate for untreated, symptomatic HCC is < 5% (El-Serag and Mason, 1999), whereas the 5-year survival rate in patients with cirrhosis who have a small (< 2 cm) HCC lesion and undergo liver transplantation is 80%; therefore, the detection of small HCC is highly critical to patient outcome (Mazzaferro et al., 1996).
KeywordsHepatocellular Carcinoma Arterial Phase Cirrhotic Liver Portal Venous Phase Dysplastic Nodule
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