Abstract
The aim of this chapter is to outline the principles of chemical category formation and the use of read-across methods to fill data gaps to aid regulatory toxicological decision making. The chapter outlines the Organisation for Economic Co-operation and Development (OECD) principles for the design of a chemical category. This section aims to give a flavour of the steps that need to be considered when forming a chemical category. This is followed by a description of the advantages that considering chemicals within categories bring in risk assessment. The importance of how to define chemical similarity and several commonly used methods is discussed. Finally a brief review of the limited literature available showing actual examples of read-across methods is presented
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The funding of the European Union Sixth Framework CAESAR Specific Targeted Project (SSPI-022674-CAESAR) is gratefully acknowledged.
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Enoch, S.j. (2010). Chemical Category Formation and Read-Across for the Prediction of Toxicity. In: Puzyn, T., Leszczynski, J., Cronin, M. (eds) Recent Advances in QSAR Studies. Challenges and Advances in Computational Chemistry and Physics, vol 8. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-9783-6_7
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