Overexpression of Conserved Kinase UNC-51 Inhibits the Transferrin's Endocytosis into the Mammalian Cells
UNC-51 overexpression can inhibit the transferrin endocytosis in the transfected COS-7 cells. We think that this inhibition of transferrin endocytosis should be caused by UNC-51-dependent microtubule-disruption (being submitted to Science Signaling).
Keywordskinase UNC-51 tubulin actin dynamics endocytosis transferrin
We are very thankful to Drs. K. Hayashi and T. Tahira, T. Tani, K. Nakayama, A. Yamanaka, K. Mizuno, K. Tawada, Y. Emoto, H. Arata, K. Katayama, Y. Fujiki, Y. Fukumaki, M. Kimura, S. Osaki, I. Ito and Y. Kato for kindly providing pCAGGS vector, COS cells, HeLa cells, HEK293T cells, pUcD2SRαMCS, Beckman Optima centrifuge, French press, the computer system, kind discussion, advice, help and encouragement. We express sincere gratitude to all members of both laboratories for their help and encouragement.