Anti-melanogenic Activity of Ergosterol Peroxide from Ganoderma lucidum on a Mouse Melanoma Cell Line

  • Toshiyuki Mukaiyama
  • Noriyuki Tsujimura
  • Shoko Otaka
  • Yasuyuki Kosaka
  • Keishi Hata
  • Kazuyuki Hori
  • Kenji Sakamoto
Conference paper
Part of the Animal Cell Technology: Basic & Applied Aspects book series (ANICELLTECH, volume 15)

Abstract

MeOH extracts of Ganoderma lucidum showed an inhibitory effect on melanin biosynthesis of a mouse melanoma cell line, B16 10F7. We isolated an active compound from the extract. Physical and chemical data of the active compound were identical to those of ergosterol peroxide. Ergosterol peroxide decreased melanin pigment accumulation over 1 μg/ml by the suppression of melanogenic enzyme in B16 10F7 cells. However, ergosterol, a typical steroid in mushrooms, did not show a marked inhibitory effect on B16 10F7 cell melanogenesis at the same concentrations.

Keywords

Melanin Ganoderma lucidum ergosterol peroxide whiteness B16 cells 

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Copyright information

© Springer Science+Business Media B.V. 2008

Authors and Affiliations

  • Toshiyuki Mukaiyama
    • 1
  • Noriyuki Tsujimura
    • 1
  • Shoko Otaka
    • 1
  • Yasuyuki Kosaka
    • 1
  • Keishi Hata
    • 2
  • Kazuyuki Hori
    • 2
  • Kenji Sakamoto
    • 1
  1. 1.Sakamoto Bio Co., Ltd.AkitaJapan
  2. 2.Akita Research Institute for Food & Brewing (ARIF)AkitaJapan

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