Anti-melanogenic Activity of Ergosterol Peroxide from Ganoderma lucidum on a Mouse Melanoma Cell Line
MeOH extracts of Ganoderma lucidum showed an inhibitory effect on melanin biosynthesis of a mouse melanoma cell line, B16 10F7. We isolated an active compound from the extract. Physical and chemical data of the active compound were identical to those of ergosterol peroxide. Ergosterol peroxide decreased melanin pigment accumulation over 1 μg/ml by the suppression of melanogenic enzyme in B16 10F7 cells. However, ergosterol, a typical steroid in mushrooms, did not show a marked inhibitory effect on B16 10F7 cell melanogenesis at the same concentrations.
KeywordsMelanin Ganoderma lucidum ergosterol peroxide whiteness B16 cells
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