Introduction: Colorectal Cancer
An immense burden is associated with cancer worldwide. This is especially evident among citizens of developing countries. A case in point is that approximately 500,000 women develop cervical cancer each year worldwide, resulting in 250,000 deaths, and 80% of this cancer occurs in developing countries. Many factors, including socio-economic status, cultural perception of malignant conditions, the cost of anticancer chemotherapy, and the paucity of radiation and hospital facilities, (i.e., cancer screening), insufficient transmission of oncology-related information, and, most importantly, inadequate diet, are responsible for the suffering among those in the developing world. Although efforts are being undertaken by private organizations and institutions for reducing the burden of cancer in developing countries, it is evident that governments of developed countries could do much more to address the problem.
Because significant improvements in the prevention and treatment of cardiovascular diseases have occurred, cancer will become the leading cause of death in many parts of the world. In addition, cancer will remain a major health problem, as population aging continues in many countries and elderly persons are more susceptible to this form of malignancy. Approximately, 60% of cancer incidence and 70% of cancer mortality occur among older adults (65 years and older). Unfortunately, it should be noted that cancer care for frail older adults has been mostly unrepresented in clinical trials.
KeywordsColorectal Cancer Rectal Cancer Colorectal Liver Metastasis Compute Tomography Colonography Colorectal Cancer Screening
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- Avallone, A., Delrio, P., Guida, C., Tatangelo, F., Petrillo, A., Lastoria, S., Parisi, V., Comella, G., Budillon, A., and Comella, P. 2007. High rate of TRG1-2 and prolonged RFS with OXA/ TOM and FU/LFA during preoperative pelvic RT in patients with poor prognosis locally advanced rectal cancer (LARC). J. Clin. Oncol. 25: 14500.Google Scholar
- Bronner, C.E., Baker, S.M., Morrison, P.T., Warren, G., Smith, L.G., Lescoe, M.K., Kane, M., Earabino, C., Lipford, J., Lindblom, A., Tannergard, P., Bollag, R.J., Godwin, A.R., Ward, D.C., Nordenskjold, M., Fishel, R., Kolodner, R., Liskay, R.M. 1994. Mutation in the DNA mismatch repair gene homologue hMLHI is associated with hereditary nonpolyposis colon cancer. Nature 368: 258–261.PubMedCrossRefGoogle Scholar
- Giantonio, B.J., Catalano, P.J., Meropol, N.J., O'Dwyer, P.J., Mitchell, E.P., Alberts, S.R., Schwartz, M.A., and Benson III, A.B. 2007. Bevacizumab in combination with oxaliplatin, fluorouracil, and leucovorin (FOLFOX4) for previously treated metastatic colorectal cancer: results from the Eastern Cooperative Oncology Group Study E3200. J. Clin. Oncol. 25: 1539–1544.PubMedCrossRefGoogle Scholar
- Goldberg, R.M., Sargent, D.J., Morton, R.F., Fuchs, C.S., Ramanathan, R.K., Williamson, S.K., Findlay, B.P., Pitot, H.C., and Alberts, S. 2006. Randomized controlled trial of reduced-dose bolus fluorouracil plus leucovorin and irino-tecan or infused fluorouracil plus oxaliplatin in patients with previously untreated metastatic colorectal cancer: a North American Intergroup Trial. J. Clin. Oncol. 24: 3347–3352.PubMedCrossRefGoogle Scholar
- Johnson, K.T., Carston, M.J., Wentz, R.J., Manduca, A., Anderson, S.M., and Johnson, C.D. 2007. Development of cathartic-free colorectal cancer screening. Test using virtual colonoscopy: a feasibility study. Am. J. Radiol. 188: W29–W36.Google Scholar
- Pawlik, T.M., Scoggins, C.R., Zorzi, D., Abdalla, E.K., Andres, A., Eng, C., Curley, S.A., Loyer, E., Muratore, A., Mentha, G., Caoussotti, L., and Vauthey, J.N. 2005. Effects of surgical margin status on survival and site recurrence after hepatic resection for colorectal metastases. Ann. Surg. 241: 715–722.PubMedCrossRefGoogle Scholar
- Ren, J., Xiao, Y.J., Singh, L.S., Zhao, X., Zhao, Z., Feng, L., Rose, T.M., Prestwich, G.D., and Xu, Y. 2006. Lysophosphatidic acid is continually produced by human peritoneal mesothelial cells and enhances adhesion, migration and invasion of ovaria cancer cells. Cancer Res. 66: 3006–3014.PubMedCrossRefGoogle Scholar
- Rockey, D.C., Paulson, E., Niedzwiechi, D., Davis, W., Bosworth, H.B., Sanders, L., Yee, J., Henderson, J., Haften, P., Burdich, S., Sanyal, A., Rubin, D.T., Sterlin, M., Aberkar, G., Bhutani, M.S., Binmoeller, K., Garvie, J., Bini, E.J., McQuaid, K., Foster, W.L., Thompson, W.M., Dachman, A., and Halvorsen, R. 2005. Analysis of air contrast barium enema, computed tomo-graphic colonography and colonoscopy: prospective comparison. Lancet 365: 305–311.PubMedGoogle Scholar
- Simiantonaki, N., Kurzik-Dumke, U., Karyofylli, G., Tayasinghe, C., Michel-Schmidt, R., and Kirkpatrick, C.J. 2007. Reduced expression of TLR4 is associated with the metastatic status of human colorectal cancer. Inter. J. Mol. Med. 20: 21–29.Google Scholar