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Disposition of Nanoparticles as a function of Their Interactions with Biomolecules

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Nanomaterials: Risks and Benefits

Abstract

This review focuses on emerging concepts in the fundamental understanding of how particle surfaces interact with components in biological fluids, with an emphasis on how these interactions may inform research regarding the biodistribution of nanosized materials from the portal of entry to other organ systems. The respiratory tract is given particular focus here because of expected occupational and environmental exposure scenarios. Information regarding the biodistribution of nanoparticles and how they might be altered during the process by their local environment is a critical part of a complete human health risk assessment.

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Author information

Authors and Affiliations

  1. Centre for BioNano Interactions School of Chemistry and Chemical Biology University College Dublin Belfield, Dublin 4, Ireland

    I. Lynch

  2. Department of Environmental Medicine, University of Rochester, 575 Elmwood Avenue, Box 850, Rochester, NY 14610, USA

    A. Elder

Authors
  1. I. Lynch
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  2. A. Elder
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Editor information

Editors and Affiliations

  1. US Army Engineer Research and Development Center Concord, Massachusetts, U.S.A.

    Igor Linkov

  2. US Army Engineer Research and Development Center Vicksburg, Mississippi, U.S.A.

    Jeffery Steevens

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Lynch, I., Elder, A. (2009). Disposition of Nanoparticles as a function of Their Interactions with Biomolecules. In: Linkov, I., Steevens, J. (eds) Nanomaterials: Risks and Benefits. NATO Science for Peace and Security Series C: Environmental Security. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-9491-0_2

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