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The Handbook of Neuropsychiatric Biomarkers, Endophenotypes and Genes pp 57–86Cite as

Translational Medicine: Functional Biomarkers for Drug Development of “Cognitive Enhancers” in Schizophrenia

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Abstract

Biomarkers are the bridge between basic and clinical research and enable us to speed up the pro cess of drug development. In the process of drug devel opment of “cognitive enhancers” for the treatment of schizophrenia, the usefulness of biomarkers is increas ingly realized. In this chapter, we will introduce the concept of biomarkers and discuss its application with regard to drugs that are developed for the purpose of cognitive enhancement in schizophrenia. While focus sing on functional biomarkers, i.e., functional mag netic resonance imaging (fMRI) and electrophysiology (EEG), it will be clearly delineated what is currently feasible, what kind of limitations still exist and what needs to be done in the future to optimise the available functional biomarkers. In addition, those functional biomarkers are listed which are thought to qualify as biomarkers for cognitive defi cits in schizophrenia or which are at least close to what one may call a valid biomarker for drug development.

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Authors and Affiliations

  1. Department of Psychiatry, Heinrich-Heine University, Duesseldorf, Germany

    Georg Winterer (Associate Professor)

  2. Institute of Neurosciences and Biophysics, Juelich Research Centre, Juelich, Germany

    Georg Winterer (Associate Professor)

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  1. Israel Institute of Technology, Haifa

    Michael S. Ritsner M.D., Ph.D. (Associate Professor of Psychiatry, the Rappaport Faculty of Medicine Technion) (Associate Professor of Psychiatry, the Rappaport Faculty of Medicine Technion)

  2. Sha'ar Menashe Mental Health Center, Hadera, Israel

    Michael S. Ritsner M.D., Ph.D. (Associate Professor of Psychiatry, the Rappaport Faculty of Medicine Technion) (Associate Professor of Psychiatry, the Rappaport Faculty of Medicine Technion)

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Winterer, G. (2009). Translational Medicine: Functional Biomarkers for Drug Development of “Cognitive Enhancers” in Schizophrenia. In: Ritsner, M.S. (eds) The Handbook of Neuropsychiatric Biomarkers, Endophenotypes and Genes. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-9464-4_4

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