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Handbook on Immunosenescence pp 713–726Cite as

Mitochondria and Immunosenescence

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The immune system undergoes age-associated changes, that affect its response to infections and cancer, and contributes to the organism’s aging and its associated pathologies. An eminent hypothesis to explain the aging process, most supported by experimental data, is the mitochondrial free radical theory. Evidence is accumulating, linking mitochondrial oxidative damage and apoptosis to immunosenescence.

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Author information

Authors and Affiliations

  1. The Department of Medicine, University Hospital Kerem, Kerem

    Pazit Beckerman & Arie Ben Yehuda

Authors
  1. Pazit Beckerman
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  2. Arie Ben Yehuda
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Editor information

Editors and Affiliations

  1. Research Center on Aging, Department of Medicine, Immunology Graduate Programme, Faculty of Medicine, University of Sherbrooke, 1036 Rue Belvedere, J1H 4C4, Sherbrooke, Quebec, Canada

    Tamas Fulop

  2. Department of Experimental Pathalogy, CIG Interdepartmental Center “L. Galvani” University of Bologna, Via San Giacomo 12, 40126, Bologna, Italy

    Claudio Franceschi

  3. Institute for Health and Life Sciences, 4-6-22 Kohinato, Bunkyo-ku, Tokyo, 112-0006, Japan

    Katsuiku Hirokawa

  4. ZMF - Zentrum Med. Forschung Abt. Transplant./ Immunologie, University of Tübingen, Waldhörnlestr. 22, 72072, Tübingen, Germany

    Graham Pawelec

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Beckerman, P., Ben Yehuda, A. (2009). Mitochondria and Immunosenescence. In: Fulop, T., Franceschi, C., Hirokawa, K., Pawelec, G. (eds) Handbook on Immunosenescence. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-9063-9_37

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