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The Effects of Age on CD1d-restricted NKT-cells and Their Contribution to Peripheral T-cell Immunity

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Handbook on Immunosenescence

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Natural Killer T (NKT) cells are innate lymphocytes known for their roles in regulation of immune responses in cancer, autoimmunity, bacterial and viral infections, and the induction of immunologic tolerance [ 1–4 ]. Recently, our laboratory and others have also identified crucial roles for NKT-cells in the regulation of the host response to injury and sepsis [5–7]. As we will discuss further in this chapter, NKT-cells are now widely accepted as critical players in the initiation of maintenance of host defense, as they are uniquely poised to modulate multiple aspects of protective immunity. NKT-cells fill this position via their ability to rapidly produce significant quantities of immunomodulatory cytokines very early during the course of the immune response and can thereby influence the outcome of both innate and adaptive immune processes.

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Authors and Affiliations

  1. Loyola University Medical Center, Bldg 110, Rm 4236 2160 South First Avenue, Maywood, IL, 60153, USA

    Douglas E. Faunce & Jessica L. Palmer

Authors
  1. Douglas E. Faunce
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  2. Jessica L. Palmer
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Editors and Affiliations

  1. Research Center on Aging, Department of Medicine, Immunology Graduate Programme, Faculty of Medicine, University of Sherbrooke, 1036 Rue Belvedere, J1H 4C4, Sherbrooke, Quebec, Canada

    Tamas Fulop

  2. Department of Experimental Pathalogy, CIG Interdepartmental Center “L. Galvani” University of Bologna, Via San Giacomo 12, 40126, Bologna, Italy

    Claudio Franceschi

  3. Institute for Health and Life Sciences, 4-6-22 Kohinato, Bunkyo-ku, Tokyo, 112-0006, Japan

    Katsuiku Hirokawa

  4. ZMF - Zentrum Med. Forschung Abt. Transplant./ Immunologie, University of Tübingen, Waldhörnlestr. 22, 72072, Tübingen, Germany

    Graham Pawelec

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Faunce, D.E., Palmer, J.L. (2009). The Effects of Age on CD1d-restricted NKT-cells and Their Contribution to Peripheral T-cell Immunity. In: Fulop, T., Franceschi, C., Hirokawa, K., Pawelec, G. (eds) Handbook on Immunosenescence. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-9063-9_29

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