The Effects of Age on CD1d-restricted NKT-cells and Their Contribution to Peripheral T-cell Immunity
Natural Killer T (NKT) cells are innate lymphocytes known for their roles in regulation of immune responses in cancer, autoimmunity, bacterial and viral infections, and the induction of immunologic tolerance [ 1–4 ]. Recently, our laboratory and others have also identified crucial roles for NKT-cells in the regulation of the host response to injury and sepsis [5–7]. As we will discuss further in this chapter, NKT-cells are now widely accepted as critical players in the initiation of maintenance of host defense, as they are uniquely poised to modulate multiple aspects of protective immunity. NKT-cells fill this position via their ability to rapidly produce significant quantities of immunomodulatory cytokines very early during the course of the immune response and can thereby influence the outcome of both innate and adaptive immune processes.
KeywordsAged Mouse Delay Type Hypersensitivity Response Glycolipid Antigen CD1d Molecule CD1d Expression
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