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NK Cells in Human Ageing

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Handbook on Immunosenescence

Abstract

NK cells are cytotoxic lymphocytes that are involved in the early defense against virus infected and tumor cells. NK cells exhibit the capacity to distinguish normal and damaged cells as well as self- and foreign cells. Besides their cytotoxic capacity NK cells also regulate the immune response by producing cytokines and chemokines that directly participate in the elimination of pathogens or activate other cellular components of immunity. NK cells express a broad range of activating receptors and their function is controlled by inhibitory receptors specific for the MHC class I molecules that are ubiquitously expressed on target cells.

Several alterations have been described in human NK cell function with advancing ageing, therefore contributing to immunosenescence. Thus whereas healthy elderly, including centenarians, have preserved NK cell number and function, a decrease in NK cell activity is associated to increased incidence of infectious and inflammatory diseases and to increased risk of death due to infection. Here, we describe recent data about the effects of ageing on NK cells.

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Authors and Affiliations

  1. Department of Immunology, Reina Sofia University Hospital University of Córdoba, Córdoba, Spain

    Inmaculada Gayoso, Corona Alonso, Corona Alonso, Esther Peralbo & Rafael Solana

  2. Immunology Unit Department of Physiology, University of Extremadura, Cáceres, Spain

    Raquel Tarazona, Javier G. Casado, Beatriz Sánchez-Correa & Sara Morgado

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  1. Raquel Tarazona
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  2. Inmaculada Gayoso
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  4. Corona Alonso
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  5. Esther Peralbo
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  7. Beatriz Sánchez-Correa
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  8. Sara Morgado
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  9. Rafael Solana
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Editors and Affiliations

  1. Research Center on Aging, Department of Medicine, Immunology Graduate Programme, Faculty of Medicine, University of Sherbrooke, 1036 Rue Belvedere, J1H 4C4, Sherbrooke, Quebec, Canada

    Tamas Fulop

  2. Department of Experimental Pathalogy, CIG Interdepartmental Center “L. Galvani” University of Bologna, Via San Giacomo 12, 40126, Bologna, Italy

    Claudio Franceschi

  3. Institute for Health and Life Sciences, 4-6-22 Kohinato, Bunkyo-ku, Tokyo, 112-0006, Japan

    Katsuiku Hirokawa

  4. ZMF - Zentrum Med. Forschung Abt. Transplant./ Immunologie, University of Tübingen, Waldhörnlestr. 22, 72072, Tübingen, Germany

    Graham Pawelec

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Tarazona, R. et al. (2009). NK Cells in Human Ageing. In: Fulop, T., Franceschi, C., Hirokawa, K., Pawelec, G. (eds) Handbook on Immunosenescence. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-9063-9_27

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