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Synergistic Effects of Ageing and Stress on Neutrophil Function

  • Chapter
Handbook on Immunosenescence

Abstract

Although ageing is a complex process, we now know much of what happens with age at the cellular and tissue level. In contrast, our understanding of how the various age-related changes interact to result in frailty and pathology is incomplete. For example, ageing is accompanied by a loss of immune function (Immunesenescence), an increase in the level of circulating proinflammatory cytokines (Inflammaging), a decline in adrenal androgen production (Adrenopause) whilst concurrently peripheral glucocorticoid availability increases. In this article we propose that these changes in combination increase the susceptibility of older adults to the adverse effects of physical and emotional stress, exacerbating the age-related decline in immune competence and exposing the older individual to increased risk of infections. We have focused upon the effects of stress and ageing on neutrophil function, an element of the immune system that has received less attention from immunogerontologists, despite the primary role of neutrophils in fighting bacterial infections and the major contribution of such infections to agerelated morbidity and mortality. We propose that physical and emotional stressors elicit an exaggerated response in older adults that synergises with the age-related loss of neutrophil function, to compromise antibacterial mechanisms. Moreover, the molecular basis of this effect may lie with the significant changes in tissue concentrations of cortisol and dehydroepiandrosterone in peripheral target cells including the immune compartment.

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Authors and Affiliations

  1. MRC Centre for Immune Regulation, Division of Immunity and Infection, Birmingham University Medical School, Birmingham, B15 2TT, UK

    Janet M. Lord

  2. School of Sport and Exercise Science, Birmingham University Medical School, Birmingham, B15 2TT, UK

    Anna C. Phillips

  3. Division of Medical Sciences, University of Birmingham, Birmingham, B15 2TT, UK

    Wiebke Arlt

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  1. Janet M. Lord
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  2. Anna C. Phillips
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  3. Wiebke Arlt
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Editor information

Editors and Affiliations

  1. Research Center on Aging, Department of Medicine, Immunology Graduate Programme, Faculty of Medicine, University of Sherbrooke, 1036 Rue Belvedere, J1H 4C4, Sherbrooke, Quebec, Canada

    Tamas Fulop

  2. Department of Experimental Pathalogy, CIG Interdepartmental Center “L. Galvani” University of Bologna, Via San Giacomo 12, 40126, Bologna, Italy

    Claudio Franceschi

  3. Institute for Health and Life Sciences, 4-6-22 Kohinato, Bunkyo-ku, Tokyo, 112-0006, Japan

    Katsuiku Hirokawa

  4. ZMF - Zentrum Med. Forschung Abt. Transplant./ Immunologie, University of Tübingen, Waldhörnlestr. 22, 72072, Tübingen, Germany

    Graham Pawelec

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Lord, J.M., Phillips, A.C., Arlt, W. (2009). Synergistic Effects of Ageing and Stress on Neutrophil Function. In: Fulop, T., Franceschi, C., Hirokawa, K., Pawelec, G. (eds) Handbook on Immunosenescence. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-9063-9_24

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