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Signal Transduction Changes in fMLP, TLRs, TREM-1 and GM-CSF Receptors in PMN with Aging

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Book cover Handbook on Immunosenescence

Abstract

It is well known that the immune response is decreased with aging leading to a higher susceptibility to infections, cancers and autoimmune disorders. The most widely studied alterations are relative to the adaptive immune response. Recently, the role of the innate immune response as first line of defence against bacterial invasion and modulator of the adaptive immune response has been widely recognized. One of the most important cell components of the innate response is neutrophils. It is now accepted that neutrophil functions are changed with age however the degree of these changes is still debated. With aging there is an alteration of the receptor driven functions of human neutrophils, such as superoxide anion production, chemotaxis and apoptosis. One of the alterations underlying these functional changes is the decrease of the receptor signalling elicited by specific receptors. Alterations were also found in the neutrophil membrane lipid rafts. These alterations in neutrophils functions and signal transduction occurring with aging might contribute to the increased infections with aging.

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Authors and Affiliations

  1. Clinical research Center, Graduate Immunology Program, Division of Pulmonology, Department of Medicine, Faculty of Medicine, University of Sherbrooke, Sherbrooke, Quebec, Canada

    Carl F. Fortin

  2. Center for Medical Research, Section for Transplant-Immunology and Immuno-Hematology, Tuebingen Aging and Tumor Immunology group, University of Tuebingen Medical School, Waldhörnlestr. 22, D-72072, Tübingen, Germany

    Anis Larbi

  3. Clinical research Center, Department of Biochemistry, Immunology Graduate Programme, Faculty of Medicine, University of Sherbrooke, Sherbrooke, Quebec, Canada

    Gilles Dupuis

  4. Research Center on Aging, Department of Medicine, Immunology Graduate Programme, Faculty of Medicine, University of Sherbrooke, Sherbrooke, Quebec, Canada

    Tamas Fulop

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Editors and Affiliations

  1. Research Center on Aging, Department of Medicine, Immunology Graduate Programme, Faculty of Medicine, University of Sherbrooke, 1036 Rue Belvedere, J1H 4C4, Sherbrooke, Quebec, Canada

    Tamas Fulop

  2. Department of Experimental Pathalogy, CIG Interdepartmental Center “L. Galvani” University of Bologna, Via San Giacomo 12, 40126, Bologna, Italy

    Claudio Franceschi

  3. Institute for Health and Life Sciences, 4-6-22 Kohinato, Bunkyo-ku, Tokyo, 112-0006, Japan

    Katsuiku Hirokawa

  4. ZMF - Zentrum Med. Forschung Abt. Transplant./ Immunologie, University of Tübingen, Waldhörnlestr. 22, 72072, Tübingen, Germany

    Graham Pawelec

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Fortin, C.F., Larbi, A., Dupuis, G., Fulop, T. (2009). Signal Transduction Changes in fMLP, TLRs, TREM-1 and GM-CSF Receptors in PMN with Aging. In: Fulop, T., Franceschi, C., Hirokawa, K., Pawelec, G. (eds) Handbook on Immunosenescence. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-9063-9_23

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