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Handbook on Immunosenescence pp 29–62Cite as

Lymphocytes Sub-Types and Functions in Centenarians as Models for Successful Ageing

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Abstract

Several cell subsets participate to the immune response, and their close interplay is fundamental for the successful elimination of harmful pathogens. In addition, a tight regulation of the immune response has to occur in order to avoid excessive inflammation and potential autoreactivity towards self components. In the last years, the discovery and the characterization of new lymphocytes subsets, including regulatory T (Treg)-cells and Natural Killer T (NKT)-cells allowed a better understanding of how an effector immune response is induced and therefore down-modulated. During the ageing of the immune system, a process termed immunosenescence, these subsets undergo a profound remodelling, both in phenotype and function. In this chapter, we will describe the essential features of lymphocyte populations in centenarians and the differences that occur with unsuccessfully aged people.

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Authors and Affiliations

  1. Chair of Immunology, Department of Biomedical Sciences, University of Modena and Reggio Emilia, 41100, Modena, Italy

    Enrico Lugli, Leonarda Troiano, Marcello Pinti, Milena Nasi, Erika Roat, Roberta Ferraresi, Linda Bertoncelli, Lara Gibellini, Elisa Nemes & Andrea Cossarizza

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  1. Enrico Lugli
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  2. Leonarda Troiano
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  3. Marcello Pinti
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  4. Milena Nasi
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  7. Linda Bertoncelli
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Editors and Affiliations

  1. Research Center on Aging, Department of Medicine, Immunology Graduate Programme, Faculty of Medicine, University of Sherbrooke, 1036 Rue Belvedere, J1H 4C4, Sherbrooke, Quebec, Canada

    Tamas Fulop

  2. Department of Experimental Pathalogy, CIG Interdepartmental Center “L. Galvani” University of Bologna, Via San Giacomo 12, 40126, Bologna, Italy

    Claudio Franceschi

  3. Institute for Health and Life Sciences, 4-6-22 Kohinato, Bunkyo-ku, Tokyo, 112-0006, Japan

    Katsuiku Hirokawa

  4. ZMF - Zentrum Med. Forschung Abt. Transplant./ Immunologie, University of Tübingen, Waldhörnlestr. 22, 72072, Tübingen, Germany

    Graham Pawelec

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Lugli, E. et al. (2009). Lymphocytes Sub-Types and Functions in Centenarians as Models for Successful Ageing. In: Fulop, T., Franceschi, C., Hirokawa, K., Pawelec, G. (eds) Handbook on Immunosenescence. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-9063-9_2

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