Abstract
Novel biosensor concepts are being explored for the transduction of affinity-based interactions into electrical signals. The specificity of affinity-based biosensors depends on the molecular recognition properties of receptors, for example antibodies, or on the hybridization of complementary nucleic acids. In this chapter, various transducer technologies for the detection of affinity-based interactions will be discussed, focusing on the exploitation of microelectronics. Several examples of label-free detection will be given and impedimetric and plasmonic biosensors will be discussed into detail. In addition, one particular example where the use of labels makes sense will be highlighted by elaborating on magnetic biosensors. In this approach, magnetic particles can be used for sample preparation as well as detection, which allows an entry into the lab-on-chip field.
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Laureyn, W., Lagae, L. (2009). Microelectronics-Based Biosensors for the Detection of Proteins and Nucleic Acids. In: Baraton, MI. (eds) Sensors for Environment, Health and Security. NATO Science for Peace and Security Series C: Environmental Security. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-9009-7_21
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DOI: https://doi.org/10.1007/978-1-4020-9009-7_21
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