Abstract
Bioinformatics is the field of science in which biology, computer science, and information technology merge to form a single discipline. More specifically the field conceptualizes biology in terms of physico-chemical aspects of molecules and then applies informatic techniques (maths, computer science and statistics) to understand and organize this information on a large-scale. The ultimate goal of the field is to enable the discovery of new biological insights as well as to create a global perspective from which unifying principles in biology can be discerned. At the beginning of the “genomic revolution”, a bioinformatics concern was the creation and maintenance of a database to store biological information, such as nucleotide and amino acid sequences. Development of this type of database involved not only design issues but the development of complex interfaces whereby researchers could both access existing data as well as submit new or revised data. Ultimately, however, all of this information must be combined to form a comprehensive picture of normal cellular activities so that researchers may study how these activities are altered in different disease stages. Therefore, the field of bioinformatics has evolved such that the most pressing task now involves the analysis and interpretation of various types of data, including nucleotide and amino acid sequences, protein domains, and protein structures.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Branden, C. and Tooze, J. (1998). Introduction to protein structure. Garland Publishing Inc., New York.
Carter Jr., C.W. and Sweet, R.M. (1997a). Macromolecular Crystallography, Part A. Meth. Enzymol., 276, Academic Press, San Diego.
Carter Jr., C.W. and Sweet, R.M. (1997b). Macromolecular Crystallography, Part A. Meth. Enzymol. 277, Academic Press, San Diego.
Chothia, C., Levitt, M. and Richardson, D. (1977). Structure of proteins: Packing of alpha helices and beta sheets. Proc. Natl. Acad. Sci. USA, 74: 4130–4134.
Chothia, C. (1984). Principles that determine the structure of proteins. Ann. Rev. Biochem., 53: 537–572.
Greer, J. (1991). Comparative modeling of homologous proteins. Meth. Enzymol., 202: 239–252.
Johnson, M.S., Srinivasan, N., Sowdhamini, R. and Blundell, T.L. (1994). Knowledge-based protein modeling. Crit. Rev. Biochem. Mol. Biol., 29: 1–68.
Lesk, A.M. (1991). Protein architecture: A practical approach. Oxford University Press, New York.
McPherson, A. (2003). Introduction to Macromolecular Crystallography. John Wiley & Sons, Hoboken, NJ.
Mount, D. (2004). Bioinformatics: Sequence and genome analysis. Cold Spring Harbor Laboratory Press, New York.
Norvell, J.C. and Machalek, A.Z. (2000). Structural genomics programs at the US National Institute of General Medical Sciences. Nat. Struct. Mol. Biol., 7: 931.
Rao, S.T. and Rossman, M.G. (1973). Comparison of super-secondary structures in proteins. J. Mol. Biol., 76: 241–256.
Richardson, J.S. (1981). The anatomy and taxonomy of protein structure. Adv. Prot. Chem., 34: 167–339.
Rossmann, M.G. and Arnold, E. (Eds.) (2006). International tables for Crystallography. Volume F: Crystallography of biological molecules. International Union of Crystallography, Chester, UK.
Subramaniam, E. (2001). G.N. Ramachandran. Nat. Struct. Mol. Biol., 8: 489–491.
Vijayan, M., Yathindra, N. and Kolaskar, A.S. (2000). Perspectives in structural biology. Universities Press (India) Ltd., Hyderabad.
Vijayan, M. (2005). Structural biology of mycobacterial proteins: The Bangalore effort. Tuberculosis (Edinb.), 85: 357–366.
Vijayan, M. (2007). Peanut lectin crystallography and macromolecular structural studies in India. J. Biosci., 32: 1059.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2009 Capital Publishing Company
About this chapter
Cite this chapter
Singh, D.D. (2009). Bioinformatics—Structural Biology Interface. In: Fulekar, M.H. (eds) Bioinformatics: Applications in Life and Environmental Sciences. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-8880-3_4
Download citation
DOI: https://doi.org/10.1007/978-1-4020-8880-3_4
Publisher Name: Springer, Dordrecht
Print ISBN: 978-1-4020-8879-7
Online ISBN: 978-1-4020-8880-3
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)