Evolutionary Dynamics of Genes and Environment in Cancer Development
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Cancer development involves dynamic interplay between genes and environment, and is increasingly understood as an evolutionary process within the body of an organism. Concurrently, human predisposition for cancer may also be regarded in an evolutionary perspective, shaped by interaction of genes and environment through the generations. We have developed a theoretical model that combines this somatic and germline evolution of cancer. Key predictions have been tested and confirmed by independent studies and the model has general implications for the understanding of cancer.
KeywordsCancer evolution genetics
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