Evolutionary Dynamics of Genes and Environment in Cancer Development
Cancer development involves dynamic interplay between genes and environment, and is increasingly understood as an evolutionary process within the body of an organism. Concurrently, human predisposition for cancer may also be regarded in an evolutionary perspective, shaped by interaction of genes and environment through the generations. We have developed a theoretical model that combines this somatic and germline evolution of cancer. Key predictions have been tested and confirmed by independent studies and the model has general implications for the understanding of cancer.
KeywordsCancer evolution genetics
Unable to display preview. Download preview PDF.
- 9.Herzog CR, Bodon N, Pittman B, Maronpot RR, Massey TE, Anderson MW, You M, Devereux TR. Carcinogen-specific targeting of chromosome 12 for loss of heterozygosity in mouse lung adenocarcinomas: Implications for chromosome instability and tumor progression. Oncogene 2004 Apr 15;23(17):3033–9.CrossRefGoogle Scholar
- 12.Darwin CR. On the origin of species by means of natural selection. London: Murray, 1859.Google Scholar
- 13.Ridley M. Evolution, 3rd ed. Oxford: Blackwell Publishing, 2003.Google Scholar