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Evolutionary Dynamics of Genes and Environment in Cancer Development

Evolution of Cancer
  • Jarle Breivik
Conference paper
Part of the NATO Science for Peace and Security Series B: Physics and Biophysics book series (NAPSB)

Abstract

Cancer development involves dynamic interplay between genes and environment, and is increasingly understood as an evolutionary process within the body of an organism. Concurrently, human predisposition for cancer may also be regarded in an evolutionary perspective, shaped by interaction of genes and environment through the generations. We have developed a theoretical model that combines this somatic and germline evolution of cancer. Key predictions have been tested and confirmed by independent studies and the model has general implications for the understanding of cancer.

Keywords

Cancer evolution genetics 

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Copyright information

© Springer Science + Business Media B.V 2008

Authors and Affiliations

  • Jarle Breivik
    • 1
  1. 1.Institute of Basic Medical Science, Faculty of MedicineUniversity of OsloOsloNorway

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