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Radiation Induced Cell Deaths

  • Chapter
Targeted Radionuclide Tumor Therapy

Summary

The previous classification of radiation induced cell deaths into either necrosis or apoptosis is today recognized as too simplistic. New possibilities to make use of other death mechanisms, when treating malignant diseases with targeted therapy, include rapid or delayed apoptosis, mitotic catastrophes, autophagy or senescence induction. Targeted radioimmunotherapy typically delivers low doses with low dose-rate irradiation to tumors, and is able to induce this extended panorama of different death mechanisms, which will be discussed in this chapter.

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  1. Departments of Immunology, Diagnostic Radiology and Radiophysics, University of Umeå, SE-90185, Umeå, Sweden

    David Eriksson, Katrine Riklund, Lennart Johansson & Torgny Stigbrand

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  1. David Eriksson
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  1. Department of Immunology, University of Umea, Umea, Sweden

    Torgny Stigbrand

  2. Rudbeck Laboratory, Uppsala University, Uppsala, Sweden

    Jörgen Carlsson

  3. Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, USA

    Gregory P. Adams

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Eriksson, D., Riklund, K., Johansson, L., Stigbrand, T. (2008). Radiation Induced Cell Deaths. In: Stigbrand, T., Carlsson, J., Adams, G.P. (eds) Targeted Radionuclide Tumor Therapy. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-8696-0_12

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