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The Auger Effect in Molecular Targeting Therapy

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Book cover Targeted Radionuclide Tumor Therapy

Summary

Knowledge on the physical and biological aspects of Auger-electron emission is described and the major attempts to use such emitters in cancer therapy are discussed. Focus is on the need for nuclear localization of the Auger-electron emitters, i.e. preferably targeting the nuclear DNA, to have a good therapy effect. Delivery of Auger-electron emitters using nucleoside analogues, DNA-intercalators, minor groove binders, hormone receptor ligands and oligonucleotides are described as well as the need for nuclear localization signals in peptides and proteins.

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Abbreviations

SSB:

Single-strand break (in DNA)

DSB:

Double-strand break (in DNA)

BrdUR:

Bromodeoxyuridine

IdUR:

Iododeoxyuridine

RBE:

Relative biological effectiveness

ER:

Estrogen receptor

TFO:

Triplex-forming ologonucleotides

DMSO:

Dimethyl sulfoxide (radical scavenger)

Mbp:

Mega base pair

D0 :

Cell survival parameter that describes the exponential part of a cell survival curve of type n = no *e−D/D o

SPECT:

Single photon emission computed tomography

PET:

Positron emission tomography

NLS:

Nuclear localizing signal

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Authors and Affiliations

  1. Department of Oncology, Radiology and Clinical Immunology, Rudbeck Laboratory, Uppsala University, SE-751 85, Uppsala, Sweden

    Hans Lundqvist, Bo Stenerlöw & Lars Gedda

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  1. Hans Lundqvist
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  2. Bo Stenerlöw
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  3. Lars Gedda
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Editors and Affiliations

  1. Department of Immunology, University of Umea, Umea, Sweden

    Torgny Stigbrand

  2. Rudbeck Laboratory, Uppsala University, Uppsala, Sweden

    Jörgen Carlsson

  3. Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, USA

    Gregory P. Adams

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Lundqvist, H., Stenerlöw, B., Gedda, L. (2008). The Auger Effect in Molecular Targeting Therapy. In: Stigbrand, T., Carlsson, J., Adams, G.P. (eds) Targeted Radionuclide Tumor Therapy. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-8696-0_11

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