Abstract
Fluid mechanics, dissolved species transport and particle dynamics phenomena play major roles in normal and pathological processes occurring in the human body. Most evident on the macro-scale are the transport phenomena associated with blood flow supplying oxygen and nutrients to organs, and airflow in the lung enabling the O2 – CO2 gas exchange. On the micro-scale, it appears that complex particle-hemodynamics can trigger biochemical responses at the cellular level that could lead to stenosed arteries, aortic heart-valve failure, or aneurysm rupture.
Clearly, the study of biofluid mechanics relies greatly on the traditional and modern topics presented in Chaps. 1–8. It also benefits from advanced computational fluid-particle dynamics and computational fluid–structure interaction (FSI) simulations (see Chap. 10). Such (validated) results can be used to gain physical insight into complex flow phenomena to a depth simply not attainable with experiments alone. However, the ultimate goals on a patient-specific basis, i.e., an understanding of the biofluid transport processes and subsequently the development of therapeutic techniques or medical devices, pose major challenges. For example, on a micro-scale most biochemical processes area not well understood, i.e., comprehensive equations/models and accurate data sets are not established. Best numerical techniques for multi-scale problems with a broad range of Reynolds and Stokes numbers as well as FSI phenomena are still under development. Simulating transport phenomena in complex organs, e.g., patient-specific lung airways, requires peta-scale computing which is presently even taxing for the world’s fastest and largest supercomputer.
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Kleinstreuer, C. (2010). Biofluid Flow and Heat Transfer. In: Modern Fluid Dynamics. Fluid Mechanics and Its Applications, vol 87. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-8670-0_9
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DOI: https://doi.org/10.1007/978-1-4020-8670-0_9
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