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MicroRNAs and Regenerative Medicine

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Current Perspectives in microRNAs (miRNA)

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Regenerative medicine is a multidisciplinary field that aims to repair, replace or regenerate cells, tissues or organs. MicroRNAs are regulators of gene expression that were identified only decades ago and recently have been shown potential therapeutic value for diverse diseases. Thus, combination of microRNAs and regenerative medicine become an emerging interdisciplinary medical field that may yield new exciting possibilities for clinical medicine. In this chapter, we review the therapeutic prospects of microRNAs in regenerative medicine. On one hand, microRNAs have important functions in the differentiation and proliferation of stem cells, which have a key function in the regeneration and transplantation of organs, and are involved in mammalian development, understanding of which will benefit tissue engineers. On the other hand, microRNAs are identified as potential therapeutic target for diverse diseases, especially for cancers. Even more, some indirect evidences show that the initiation and maintenance of cancer stem cells may be under their controls. Thus accumulated understanding of microRNAs functions in different biological processes will bring new approaches for regeneration medicine.

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  1. School of Life Science and Biotechnology, Shanghai Jiao Tong University, Dongchuan Road, No. 800, Shanghai, Minhang District, 200240, China

    Ji Wu & Zhaojuan Yang

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  1. Ji Wu
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  1. University of Southern California, Los Angeles, CA, USA

    Shao-Yao Ying

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Wu, J., Yang, Z. (2008). MicroRNAs and Regenerative Medicine. In: Ying, SY. (eds) Current Perspectives in microRNAs (miRNA). Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-8533-8_9

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