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Epigenetic Regulation of miRNA in Stem Cells

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Current Perspectives in microRNAs (miRNA)

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The ability of stem cells to maintain the necessary potency to differentiate into unique progeny, as well as the process of differentiation itself, exemplifies the critical role of epigenetic regulation in modulating the expression of common genomes so as to link cellular genotype with phenotype. Various types of epigenetic regulation in the context of stem cells, and in particular that of epigenetic regulation of non-coding microRNA, hold significance during neurogenesis from a stem cell state. Potential mechanisms and discussion on the role of epigenetic regulation of miRNA expression during stem cell epigenesis and function will be put forth. Additionally, descriptions of current techniques enabling identification of key regulatory pathways involving miRNA via comprehensive expression profiling are provided.

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Authors and Affiliations

  1. Department of Human Genetics and Graduate Program in Genetics and Molecular Biology, Emory University School of Medicine, Atlanta, GA, USA

    Keith Szulwach & Peng Jin

  2. Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, NM, USA

    Xuekun Li & Xinyu Zhao

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  1. Keith Szulwach
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  2. Xuekun Li
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  4. Peng Jin
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Editors and Affiliations

  1. University of Southern California, Los Angeles, CA, USA

    Shao-Yao Ying

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Szulwach, K., Li, X., Zhao, X., Jin, P. (2008). Epigenetic Regulation of miRNA in Stem Cells. In: Ying, SY. (eds) Current Perspectives in microRNAs (miRNA). Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-8533-8_11

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