Are Stem-Like Cells Responsible for Resistance to Therapy in Breast Cancer?

  • Ciara S. O’Brien
  • Gillian Farnie
  • Sacha J. Howell
  • Robert B. Clarke

There is increasing evidence suggesting that some tumours originate from a stem cell population. Such observations appear to support the hypothesis that tumours can be generated and maintained by a small subset of undifferentiated cells able to self renew and differentiate into the bulk tumour population. Recently, cells with cancer stem cell-like properties have been identified within breast cancer tissues suggesting that a proportion of breast cancers may originate from such progenitors. Moreover, the intrinsic resistance of cancer stem cells (CSCs) to a range of chemotherapies suggests that their presence in breast cancer may also play a significant role in the development of an endocrine-resistant state. Future clarification of the role that CSCs play in such tumours, particularly in the context of therapeutic resistance, may lead to new treatment strategies for breast cancer where targeting of the CSCs specifically could lead to better and more sustained responses.

Keywords

Breast Cancer stem cells Oestrogen receptor Endocrine therapy Resistance 

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Copyright information

© Springer Science+Business Media B.V. 2009

Authors and Affiliations

  • Ciara S. O’Brien
  • Gillian Farnie
  • Sacha J. Howell
  • Robert B. Clarke
    • 1
  1. 1.Breast Biology Group School of Cancer and Imaging Sciences, Paterson Institute for Cancer ResearchUniversity of ManchesterManchesterUK

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