Potential of Stem Cells in Liver Regeneration

Part of the Advances in Biomedical Research book series (ABIR, volume 1)

Abstract

Organ transplantation currently remains the definitive cure for several liver and pancreatic disorders. However, due to a major shortage of available organs many are turning to alternative sources for whole organ or cell-based transplantation. Stem cells have been proposed as an alternative to organ transplantation. The ethical and legal issues associated with embryonic stem cells have shifted the focus to adult stem cells and their regenerative potential has been under intense investigation. In this chapter we are reviewing the latest advances in stem cell therapy in liver diseases from bench to bedside.

Keywords

Liver disease stem cells transplantation regenerative medicine immunosuppression 

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References

  1. 1.
    Arias, I.M., J.L. Boyer, N. Fausto, F.V. Chisari, D. Schachter, D.A. Shafritz, The Liver: Biology and Pathobiology. 4th ed. 2001, Philedelphia, PA: Lippincott Williams & Wilkins, 1088 ppGoogle Scholar
  2. 2.
    Ministry of Health, Annual Report of the Chief Medical Officer. 2001, London: Ministry of Health, UKGoogle Scholar
  3. 3.
    UNOS. United Network of Organ Sharing Online. http://www.unos.org/data. 2006 [cited 2006 February 21]
  4. 4.
    Fox, I.J. et alet al., Treatment of the Crigler-Najjar syndrome type I with hepatocyte transplantation. N Engl J Med, 1998. 338(20): 1422–6PubMedCrossRefGoogle Scholar
  5. 5.
    Reubinoff, B.E., M.F. Pera, C.Y. Fong, A. Trounson, A. Bongso, Embryonic stem cell lines from human blastocysts: somatic differentiation in vitro. Nat Biotechnol, 2000. 18(4): 399–404PubMedCrossRefGoogle Scholar
  6. 6.
    Thomas, E.D., Bone marrow transplantation from the personal viewpoint. Int J Hematol, 2005. 81(2): 89–93PubMedCrossRefGoogle Scholar
  7. 7.
    Pittenger, M.F. et alet al., Multilineage potential of adult human mesenchymal stem cells. Science, 1999. 284(5411): 143–7PubMedCrossRefGoogle Scholar
  8. 8.
    Bianco, P. et alet al., Bone marrow stromal stem cells: nature, biology, and potential applications. Stem Cells, 2001. 19(3): 180–92PubMedCrossRefGoogle Scholar
  9. 9.
    Herzog, E.L., L. Chai, D.S. Krause, Plasticity of marrow-derived stem cells. Blood, 2003. 102(10): 3483–93PubMedCrossRefGoogle Scholar
  10. 10.
    Orlic, D. et alet al., Mobilized bone marrow cells repair the infarcted heart, improving function and survival. Proc Natl Acad Sci U S A, 2001. 98(18): 10344–9PubMedCrossRefGoogle Scholar
  11. 11.
    Gussoni, E. et alet al., Dystrophin expression in the mdx mouse restored by stem cell transplantation. Nature, 1999. 401(6751): 390–4PubMedGoogle Scholar
  12. 12.
    Mezey, E. et alet al., Turning blood into brain: cells bearing neuronal antigens generated in vivo from bone marrow. Science, 2000. 290(5497): 1779–82PubMedCrossRefGoogle Scholar
  13. 13.
    Strom, S.C. et alet al., Hepatocyte transplantation as a bridge to orthotopic liver transplantation in terminal liver failure. Transplantation, 1997. 63(4): 559–69PubMedCrossRefGoogle Scholar
  14. 14.
    Selden, C., H. Hodgson, Cellular therapies for liver replacement. Transpl Immunol, 2004. 12(3–4): 273–88PubMedCrossRefGoogle Scholar
  15. 15.
    Neuberger, J. et alet al., Transplantation for alcoholic liver disease. Journal of Hepatology, 2002. 36(1): 130–7PubMedCrossRefGoogle Scholar
  16. 16.
    Austin, T.W., E. Lagasse, Hepatic regeneration from hematopoietic stem cells. Mech Dev, 2003. 120(1): 131–5PubMedCrossRefGoogle Scholar
  17. 17.
    Petersen, B.E. et alet al., Bone marrow as a potential source of hepatic oval cells. Science, 1999. 284(5417): 1168–70PubMedCrossRefGoogle Scholar
  18. 18.
    Theise, N.D. et alet al., Derivation of hepatocytes from bone marrow cells in mice after radiation-induced myeloablation. Hepatology, 2000. 31(1): 235–40PubMedCrossRefGoogle Scholar
  19. 19.
    Alison, M.R. et alet al., Hepatocytes from non-hepatic adult stem cells. Nature, 2000. 406(6793): 257PubMedCrossRefGoogle Scholar
  20. 20.
    Theise, N.D. et alet al., Liver from bone marrow in humans. Hepatology, 2000. 32(1): 11–6PubMedCrossRefGoogle Scholar
  21. 21.
    Korbling, M. et alet al., Hepatocytes and epithelial cells of donor origin in recipients of peripheral-blood stem cells. N Engl J Med, 2002. 346(10): 738–46PubMedCrossRefGoogle Scholar
  22. 22.
    Krause, D.S. et alet al., Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell. Cell, 2001. 105(3): 369–77PubMedCrossRefGoogle Scholar
  23. 23.
    Terai, S. et alet al., An in vivo model for monitoring trans-differentiation of bone marrow cells into functional hepatocytes. J Biochem (Tokyo), 2003. 134(4): 551–8Google Scholar
  24. 24.
    Jang, Y.Y. et alet al., Hematopoietic stem cells convert into liver cells within days without fusion. Nat Cell Biol, 2004. 6(6): 532–9PubMedCrossRefGoogle Scholar
  25. 25.
    Vassilopoulos, G., P.R. Wang, D.W. Russell, Transplanted bone marrow regenerates liver by cell fusion. Nature, 2003. 422(6934): 901–4PubMedCrossRefGoogle Scholar
  26. 26.
    Wang, X. et alet al., Cell fusion is the principal source of bone-marrow-derived hepatocytes. Nature, 2003. 422(6934): 897–901PubMedCrossRefGoogle Scholar
  27. 27.
    Takano, H. et alet al., Pleiotropic effects of cytokines on acute myocardial infarction: G-CSF as a novel therapy for acute myocardial infarction. Curr Pharm Des, 2003. 9(14): 1121–7PubMedCrossRefGoogle Scholar
  28. 28.
    Tang, J. et alet al., Mesenchymal stem cells participate in angiogenesis and improve heart function in rat model of myocardial ischemia with reperfusion. Eur J Cardiothorac Surg, 2006. 30(2): 353–61PubMedCrossRefGoogle Scholar
  29. 29.
    Chen, Z. et alet al., Overexpression of Bcl-2 attenuates apoptosis and protects against myocardial I/R injury in transgenic mice. Am J Physiol Heart Circ Physiol, 2001. 280(5): H2313–20PubMedGoogle Scholar
  30. 30.
    Wang, M. et alet al., Pretreatment with adult progenitor cells improves recovery and decreases native myocardial proinflammatory signaling after ischemia. Shock, 2006. 25(5): 454–9PubMedCrossRefGoogle Scholar
  31. 31.
    Oyagi, S. et alet al., Therapeutic effect of transplanting HGF-treated bone marrow mesenchymal cells into CCl4-injured rats. J Hepatol, 2006. 44(4): 742–8PubMedCrossRefGoogle Scholar
  32. 32.
    Sakaida, I. et alet al., Transplantation of bone marrow cells reduces CCl4-induced liver fibrosis in mice. Hepatology, 2004. 40(6): 1304–11PubMedCrossRefGoogle Scholar
  33. 33.
    Lagasse, E. et alet al., Purified hematopoietic stem cells can differentiate into hepatocytes in vivo. Nat Med, 2000. 6(11): 1229–34PubMedCrossRefGoogle Scholar
  34. 34.
    Wang, X. et alet al., Liver repopulation and correction of metabolic liver disease by transplanted adult mouse pancreatic cells. Am J Pathol, 2001. 158(2): 571–9PubMedGoogle Scholar
  35. 35.
    Jiang, Y. et alet al., Pluripotency of mesenchymal stem cells derived from adult marrow. Nature, 2002. 418(6893): 41–9PubMedCrossRefGoogle Scholar
  36. 36.
    Tse, H.F. et alet al., Angiogenesis in ischaemic myocardium by intramyocardial autologous bone marrow mononuclear cell implantation. Lancet, 2003. 361(9351): 47–9PubMedCrossRefGoogle Scholar
  37. 37.
    Assmus, B. et alet al., Transplantation of progenitor cells and regeneration enhancement in acute myocardial infarction (TOPCARE-AMI). Circulation, 2002. 106(24): 3009–17PubMedCrossRefGoogle Scholar
  38. 38.
    Perin, E.C. et alet al., Transendocardial, autologous bone marrow cell transplantation for severe, chronic ischemic heart failure. Circulation, 2003. 107(18): 2294–302PubMedCrossRefGoogle Scholar
  39. 39.
    Bartunek, J. et alet al., Intracoronary injection of CD133-positive enriched bone marrow progenitor cells promotes cardiac recovery after recent myocardial infarction: feasibility and safety. Circulation, 2005. 112(9 Suppl): I178–83PubMedGoogle Scholar
  40. 40.
    Ge, J. et alet al., Efficacy of emergent transcatheter transplantation of stem cells for treatment of acute myocardial infarction (TCT-STAMI). Heart, 2006. 92(12): 1764–7PubMedCrossRefGoogle Scholar
  41. 41.
    Janssens, S. et alet al., Autologous bone marrow-derived stem-cell transfer in patients with ST-segment elevation myocardial infarction: double-blind, randomised controlled trial. Lancet, 2006. 367(9505): 113–21PubMedCrossRefGoogle Scholar
  42. 42.
    Gaia, S. et alet al., Feasibility and safety of G-CSF administration to induce bone marrow-derived cells mobilization in patients with end stage liver disease. J Hepatol, 2006. 45(1): 13–9PubMedCrossRefGoogle Scholar
  43. 43.
    Gordon, M.Y. et alet al., Characterization and clinical application of human CD34 + stem/progenitor cell populations mobilized into the blood by granulocyte colony-stimulating factor. Stem Cells, 2006. 24(7): 1822–30PubMedCrossRefGoogle Scholar
  44. 44.
    Levicar, N. et alet al., Long-term clinical results of autologous infusion of mobilised adult bone marrow derived CD34 + cells in patients with chronic liver disease. Cell Prolif, 2008. 41: 115–25PubMedGoogle Scholar
  45. 45.
    am Esch, J.S., 2nd et alet al., Portal application of autologous CD133 + bone marrow cells to the liver: a novel concept to support hepatic regeneration. Stem Cells, 2005. 23(4): 463–70PubMedCrossRefGoogle Scholar
  46. 46.
    Terai, S. et alet al., Improved liver function in patients with liver cirrhosis after autologous bone marrow cell infusion therapy. Stem Cells, 2006. 24(10): 2292–8PubMedCrossRefGoogle Scholar
  47. 47.
    Yannaki, E. et alet al., Lasting amelioration in the clinical course of decompensated alcoholic cirrhosis with boost infusions of mobilized peripheral blood stem cells. Exp Hematol, 2006. 34(11): 1583–7PubMedCrossRefGoogle Scholar
  48. 48.
    Lyra, A.C. et alet al., Feasibility and safety of autologous bone marrow mononuclear cell transplantation in patients with advanced chronic liver disease. World J Gastroenterol, 2007. 13(7): 1067–73PubMedGoogle Scholar
  49. 49.
    Gasbarrini, A. et alet al., Rescue therapy by portal infusion of autologous stem cells in a case of drug-induced hepatitis. Dig Liver Dis., 2007. 39(9): 878–82PubMedCrossRefGoogle Scholar
  50. 50.
    Selden, C. et alet al., Histidinemia in mice: a metabolic defect treated using a novel approach to hepatocellular transplantation. Hepatology, 1995. 21(5): 1405–12PubMedGoogle Scholar
  51. 51.
    Muraca, M. et alet al., Hepatocyte transplantation as a treatment for glycogen storage disease type 1a. Lancet, 2002. 359(9303): 317–8PubMedCrossRefGoogle Scholar
  52. 52.
    Selden, A.C., H.J. Hodgson, Growth factors and the liver. Gut, 1991. 32(6): 601–3PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science + Business Media B.V 2008

Authors and Affiliations

  1. 1.Department of SurgeryImperial College LondonUK

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