Skip to main content
SpringerLink
Log in

Introduction to Clinical Research and Study Designs

  • Chapter
Essentials of Clinical Research

  • 1860 Accesses

Abstract

This chapter addresses some of the central concepts related to clinical research and what is meant by the strength of scientific evidence. We also begin to discuss the different clinical research designs along with their respective strengths and weaknesses.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Parker_Palmer. http://en.wikipedia.org/wiki/Parker_Palmer

  2. Vickers AJ. Michael Jordan won’t accept the null hypothesis: notes on interpreting high P values. Medscape. 2006; 7(1).

    Google Scholar 

  3. The Null Logic of Hypothesis Testing. http://www.shsu.edu/∼icc_cmf/cj_787/research6.doc

  4. Blackstone. Cited in The Null Logic of Hypothesis Testing. 2 Bl. Com. C. 27, margin page 358, ad finem. Available at: http://www.shsu.edu/∼icc_cmf/cj_787/research6.doc

  5. Connolly HM, Crary JL, McGoon MD, et al. Valvular heart disease associated with fenfluramine-phentermine. N Engl J Med. Aug 28, 1997; 337(9):581–588.

    Article  PubMed  CAS  Google Scholar 

  6. Cited in Sartwell P and Nathanson N. Epidemiologic Reviews. 1993.

    Google Scholar 

  7. Sacks FM, Pfeffer MA, Moye LA, et al. The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels. Cholesterol and recurrent events trial investigators. N Engl J Med. Oct 3, 1996; 335(14):1001–1009.

    Article  PubMed  CAS  Google Scholar 

  8. Doll R. Cohort studies: history of the method. II. Retrospective cohort studies. Soz Praventivmed 2001; 46(3):152–160.

    Article  PubMed  CAS  Google Scholar 

  9. von Elm E, Altman DG, Egger M, Pocock SJ, Gotzsche PC, Vandenbroucke JP. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. Ann Intern Med. Oct 16, 2007; 147(8):573–577.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Univesity of Alabama at Birmingham, Birmingham, Alabama, 1717 11th Ave. South MT 638, Birmingham, AL

    Stephen P. Glasser (Professor of Medicine and Epidemiology)

Authors
  1. Stephen P. Glasser
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. University of Alabama at Birmingham, AL, USA

    Stephen P. Glasser

Rights and permissions

Reprints and permissions

Copyright information

© 2008 Springer Science + Business Media B.V

About this chapter

Cite this chapter

Glasser, S.P. (2008). Introduction to Clinical Research and Study Designs. In: Glasser, S.P. (eds) Essentials of Clinical Research. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-8486-7_2

Download citation

  • DOI: https://doi.org/10.1007/978-1-4020-8486-7_2

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-1-4020-8485-0

  • Online ISBN: 978-1-4020-8486-7

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation