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Intestinal Bacteria: Mucosal Tissue Development and Gut Homeostasis

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Immunity Against Mucosal Pathogens

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Abstract

Intestinal microbiota affect multiple aspects of the mucosal immune system, including promotion of mucosal organogenesis, TH cytokines balance, somatic diversification of Ig genes, and production of IgA. The mechanism by which microbiota interacts with vertebrate hosts and mediates these processes remains largely unexplored. Here we discuss the organogenesis of mucosal-associated lymphoid tissues, mechanisms by which microbiota promote MALT development, and how IgA can maintain a peaceful coexistence between commensals and their host.

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Authors and Affiliations

  1. Department of Microbiology and Immunology Stritch School of Medicine, Loyola University Chicago, Maywood, IL, USA

    Katherine L. Knight

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  1. Dennis K. Lanning
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  2. Kari M. Severson
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  3. Katherine L. Knight
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Editors and Affiliations

  1. Davis School of Medicine Department of Medical Microbiology and Immunology, University of California, Davis CA 95616, USA

    Michael Vajdy

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Lanning, D.K., Severson, K.M., Knight, K.L. (2008). Intestinal Bacteria: Mucosal Tissue Development and Gut Homeostasis. In: Vajdy, M. (eds) Immunity Against Mucosal Pathogens. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-8412-6_5

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