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Influenza Virus Pathogenesis and Vaccines

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Immunity Against Mucosal Pathogens

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Abstract

Infections with seasonally prevalent strains of influenza cause a substantial healthcare burden worldwide. Influenza gains access to the host through the mucosa of the upper respiratory tract, but exerts most of its pathologic effects in the lower respiratory tract. The threat of avian influenza strains to cause bird to human and then human to human transmission and hence pandemic influenza, is serious. Thus, while improved vaccines for seasonal influenza, particularly for infants and the elderly, are sought for, new vaccines that are effective against pandemic influenza strains are urgently needed.

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References

  1. Glezen, W.P. 1982, Epidemiol Rev, 4, 25.

    PubMed  CAS  Google Scholar 

  2. Molinari, N.A., Ortega-Sanchez, I.R., Messonnier, M.L., Thompson, W.W., Wortley, P.M., Weintraub, E., and Bridges, C.B. 2007, Vaccine, 25, 5086.

    PubMed  Google Scholar 

  3. Cheung, T.K., and Poon, L.L. 2007, Ann NY Acad Sci, 1102, 1.

    PubMed  CAS  Google Scholar 

  4. Tumpey, T.M., Maines, T.R., Van Hoeven, N., Glaser, L., Solorzano, A., Pappas, C., Cox, N.J., Swayne, D.E., Palese, P., Katz, J.M., and Garcia-Sastre, A. 2007, Science, 315, 655.

    PubMed  CAS  Google Scholar 

  5. Nicholls, J.M., Chan, M.C., Chan, W.Y., Wong, H.K., Cheung, C.Y., Kwong, D.L., Wong, M.P., Chui, W.H., Poon, L.L., Tsao, S.W., Guan, Y., and Peiris, J.S. 2007, Nat Med, 13, 147.

    PubMed  CAS  Google Scholar 

  6. Stevens, J., Blixt, O., Paulson, J.C., and Wilson, I.A. 2006, Nat Rev Microbiol, 4, 857.

    PubMed  CAS  Google Scholar 

  7. Bhatia, A., and Kast, R.E. 2007, Cell Mol Biol Lett, 12, 111.

    PubMed  CAS  Google Scholar 

  8. Wright, P.F., and Webster, R.G. 2001, Fields virology, D.M. Knipe (Ed.), Lippincott Williams & Wilkins, Philadelphia, PA, 1533.

    Google Scholar 

  9. Laube, D.M., Yim, S., Ryan, L.K., Kisich, K.O., and Diamond, G. 2006, Curr Top Microbiol Immunol, 306, 153.

    PubMed  CAS  Google Scholar 

  10. Hartshorn, K.L., Ligtenberg, A., White, M.R., Van Eijk, M., Hartshorn, M., Pemberton, L., Holmskov, U., and Crouch, E. 2006, Biochem J, 393, 545.

    PubMed  CAS  Google Scholar 

  11. Salvatore, M., Garcia-Sastre, A., Ruchala, P., Lehrer, R.I., Chang, T., and Klotman, M.E. 2007, J Infect Dis, 196, 835.

    PubMed  CAS  Google Scholar 

  12. Tumpey, T.M., Szretter, K.J., Van Hoeven, N., Katz, J.M., Kochs, G., Haller, O.,Garcia-Sastre, A., and Staeheli, P. 2007, J Virol, 81, 10818.

    PubMed  CAS  Google Scholar 

  13. Crouch, E., Hartshorn, K., and Ofek, I. 2000, Immunol Rev, 173, 52.

    PubMed  CAS  Google Scholar 

  14. Tecle, T., White, M.R., Crouch, E.C., and Hartshorn, K.L. 2007, Arch Virol, 152, 1731.

    PubMed  CAS  Google Scholar 

  15. Kase, T., Suzuki, Y., Kawai, T., Sakamoto, T., Ohtani, K., Eda, S., Maeda, A., Okuno, Y., Kurimura, T., and Wakamiya, N. 1999, Immunology, 97, 385.

    PubMed  CAS  Google Scholar 

  16. Longhi, M.P., Williams, A., Wise, M., Morgan, B.P., and Gallimore, A. 2007, Eur J Immunol, 37, 1266.

    PubMed  CAS  Google Scholar 

  17. Hammerbeck, D.M., Burleson, G.R., Schuller, C.J., Vasilakos, J.P., Tomai, M., Egging, E., Cochran, F.R., Woulfe, S., and Miller, R.L. 2007, Antiviral Res, 73, 1.

    PubMed  CAS  Google Scholar 

  18. Lund, J.M., Alexopoulou, L., Sato, A., Karow, M., Adams, N.C., Gale, N.W., Iwasaki, A., and Flavell, R.A. 2004, Proc Natl Acad Sci USA, 101, 5598.

    PubMed  CAS  Google Scholar 

  19. Dessing, M.C., van der Sluijs, K.F., Florquin, S., Akira, S., and van der Poll, T. 2007, Am J Respir Cell Mol Biol, 36, 609.

    PubMed  CAS  Google Scholar 

  20. Kobasa, D., Jones, S.M., Shinya, K., Kash, J.C., Copps, J., Ebihara, H., Hatta, Y., Kim, J.H., Halfmann, P., Hatta, M., Feldmann, F., Alimonti, J.B., Fernando, L., Li, Y., Katze, M.G., Feldmann, H., and Kawaoka, Y. 2007, Nature, 445, 319.

    PubMed  CAS  Google Scholar 

  21. Herold, S., von Wulffen, W., Steinmueller, M., Pleschka, S., Kuziel, W.A., Mack, M.,Srivastava, M., Seeger, W., Maus, U.A., and Lohmeyer, J. 2006, J Immunol, 177, 1817.

    PubMed  CAS  Google Scholar 

  22. Huang, Q., Liu, D., Majewski, P., Schulte, L.C., Korn, J.M., Young, R.A., Lander, E.S., and Hacohen, N. 2001, Science, 294, 870.

    PubMed  CAS  Google Scholar 

  23. Hashimoto, Y., Moki, T., Takizawa, T., Shiratsuchi, A., and Nakanishi, Y. 2007, J Immunol, 178, 2448.

    PubMed  CAS  Google Scholar 

  24. Lee, R.M., White, M.R., and Hartshorn, K.L. 2006, Scand J Immunol, 63, 81.

    PubMed  CAS  Google Scholar 

  25. Le Goffic, R., Pothlichet, J., Vitour, D., Fujita, T., Meurs, E., Chignard, M., and Si-Tahar, M. 2007, J Immunol, 178, 3368.

    PubMed  Google Scholar 

  26. Owen, R.E., Yamada, E., Thompson, C.I., Phillipson, L.J., Thompson, C., Taylor, E.,Zambon, M., Osborn, H.M., Barclay, W.S., and Borrow, P. 2007, J Virol,81, 11170.

    PubMed  CAS  Google Scholar 

  27. Gazit, R., Gruda, R., Elboim, M., Arnon, T.I., Katz, G., Achdout, H., Hanna, J., Qimron, U., Landau, G., Greenbaum, E., Zakay-Rones, Z., Porgador, A., and Mandelboim, O. 2006, Nat Immunol, 7, 517.

    PubMed  CAS  Google Scholar 

  28. Draghi, M., Pashine, A., Sanjanwala, B., Gendzekhadze, K., Cantoni, C., Cosman, D., Moretta, A., Valiante, N.M., and Parham, P. 2007, J Immunol, 178, 2688.

    PubMed  CAS  Google Scholar 

  29. Liu, B., Mori, I., Hossain, M.J., Dong, L., Takeda, K., and Kimura, Y. 2004, J Gen Virol, 85, 423.

    PubMed  CAS  Google Scholar 

  30. Dessing, M.C., van der Sluijs, K.F., Florquin, S., and van der Poll, T. 2007, Clin Immunol, 7, 7.

    Google Scholar 

  31. Guillot, L., Le Goffic, R., Bloch, S., Escriou, N., Akira, S., Chignard, M., and Si-Tahar, M. 2005, J Biol Chem, 280, 5571.

    PubMed  CAS  Google Scholar 

  32. Heer, A.K., Shamshiev, A., Donda, A., Uematsu, S., Akira, S., Kopf, M., and Marsland, B.J. 2007, J Immunol, 178, 2182.

    PubMed  CAS  Google Scholar 

  33. Chang, W.L., Coro, E.S., Rau, F.C., Xiao, Y., Erle, D.J., and Baumgarth, N. 2007, J Immunol, 178, 1457.

    PubMed  CAS  Google Scholar 

  34. Mozdzanowska, K., Maiese, K., and Gerhard, W. 2000, J Immunol, 164, 2635.

    PubMed  CAS  Google Scholar 

  35. Jayasekera, J.P., Moseman, E.A., and Carroll, M.C. 2007, J Virol, 81, 3487.

    PubMed  CAS  Google Scholar 

  36. Baumgarth, N., Herman, O.C., Jager, G.C., Brown, L., and Herzenberg, L.A. 1999, Proc Natl Acad Sci USA, 96, 2250.

    PubMed  CAS  Google Scholar 

  37. Coro, E.S., Chang, W.L., and Baumgarth, N. 2006, J Immunol, 176, 4343.

    PubMed  CAS  Google Scholar 

  38. Denton, A.E., Doherty, P.C., Turner, S.J., and La Gruta, N.L. 2007, Eur J Immunol, 37, 368.

    PubMed  CAS  Google Scholar 

  39. Monteiro, J.M., Harvey, C., and Trinchieri, G. 1998, J Virol, 72, 4825.

    PubMed  CAS  Google Scholar 

  40. He, X.S., Draghi, M., Mahmood, K., Holmes, T.H., Kemble, G.W., Dekker, C.L., Arvin, A.M., Parham, P., and Greenberg, H.B. 2004, J Clin Invest, 114, 1812.

    PubMed  CAS  Google Scholar 

  41. Tumpey, T.M., Renshaw, M., Clements, J.D., and Katz, J.M. 2001, J Virol, 75, 5141.

    PubMed  CAS  Google Scholar 

  42. Zhang, Y., Pacheco, S., Acuna, C.L., Switzer, K.C., Wang, Y., Gilmore, X., Harriman, G.R., and Mbawuike, I.N. 2002, Immunology, 105, 286.

    PubMed  CAS  Google Scholar 

  43. Asahi-Ozaki, Y., Yoshikawa, T., Iwakura, Y., Suzuki, Y., Tamura, S., Kurata, T., and Sata, T. 2004, J Med Virol, 74, 328.

    PubMed  CAS  Google Scholar 

  44. Asahi, Y., Yoshikawa, T., Watanabe, I., Iwasaki, T., Hasegawa, H., Sato, Y., Shimada, S., Nanno, M., Matsuoka, Y., Ohwaki, M., Iwakura, Y., Suzuki, Y., Aizawa, C., Sata, T.,Kurata, T., and Tamura, S. 2002, J Immunol, 168, 2930.

    PubMed  CAS  Google Scholar 

  45. Tamura, S., Ito, Y., Asanuma, H., Hirabayashi, Y., Suzuki, Y., Nagamine, T., Aizawa, C., and Kurata, T. 1992, J Immunol, 149, 981.

    PubMed  CAS  Google Scholar 

  46. Asanuma, H., Koide, F., Suzuki, Y., Nagamine, T., Aizawa, C., Kurata, T., and Tamura, S. 1995, Vaccine, 13, 3.

    PubMed  CAS  Google Scholar 

  47. Tamura, S.I., Samegai, Y., Kurata, H., Kikuta, K., Nagamine, T., Aizawa, C., and Kurata, T. 1989, Vaccine, 7, 257.

    PubMed  CAS  Google Scholar 

  48. Tamura, S.I., Asanuma, H., Ito, Y., Hirabayashi, Y., Suzuki, Y., Nagamine, T., Aizawa, C., Kurata, T., and Oya, A. 1992, Eur J Immunol, 22, 477.

    PubMed  CAS  Google Scholar 

  49. Brandtzaeg, P. 2003, Dev Biol (Basel), 115, 39.

    CAS  Google Scholar 

  50. Tamura, S., Tanimoto, T., and Kurata, T. 2005, Jpn J Infect Dis, 58, 195.

    PubMed  CAS  Google Scholar 

  51. Mendelman, P.M., Rappaport, R., Cho, I., Block, S., Gruber, W., August, M., Dawson, D., Cordova, J., Kemble, G., Mahmood, K., Palladino, G., Lee, M.S., Razmpour, A., Stoddard, J., and Forrest, B.D. 2004, Pediatr Infect Dis J, 23, 1053.

    PubMed  Google Scholar 

  52. Lee, M.S., and Yang, C.F. 2003, J Infect Dis, 188, 1362.

    PubMed  CAS  Google Scholar 

  53. Harper, S.A., Fukuda, K., Cox, N.J., and Bridges, C.B. 2003, MMWR Recomm Rep, 52, 1.

    Google Scholar 

  54. Eichelberger, M.C., Wang, M.L., Allan, W., Webster, R.G., and Doherty, P.C. 1991, J Gen Virol, 72, 1695.

    PubMed  Google Scholar 

  55. Brown, D.M., Dilzer, A.M., Meents, D.L., and Swain, S.L. 2006, J Immunol, 177, 2888.

    PubMed  CAS  Google Scholar 

  56. Kamperschroer, C., Dibble, J.P., Meents, D.L., Schwartzberg, P.L., and Swain, S.L. 2006, J Immunol, 177, 5317.

    PubMed  CAS  Google Scholar 

  57. Debes, G.F., Bonhagen, K., Wolff, T., Kretschmer, U., Krautwald, S., Kamradt, T., and Hamann, A. 2004, J Virol, 78, 7528.

    PubMed  CAS  Google Scholar 

  58. Allan, W., Tabi, Z., Cleary, A., and Doherty, P.C. 1990, J Immunol, 144, 3980.

    PubMed  CAS  Google Scholar 

  59. Riberdy, J.M., Christensen, J.P., Branum, K., and Doherty, P.C. 2000, J Virol, 74, 9762.

    PubMed  CAS  Google Scholar 

  60. Belz, G.T., Wodarz, D., Diaz, G., Nowak, M.A., and Doherty, P.C. 2002, J Virol, 76, 12388.

    PubMed  CAS  Google Scholar 

  61. Richter, M., Ray, S.J., Chapman, T.J., Austin, S.J., Rebhahn, J., Mosmann, T.R., Gardner, H., Kotelianski, V., deFougerolles, A.R., and Topham, D.J. 2007, J Immunol, 178, 4506.

    PubMed  CAS  Google Scholar 

  62. Topham, D.J., Tripp, R.A., Sarawar, S.R., Sangster, M.Y., and Doherty, P.C. 1996, J Virol, 70, 1288.

    PubMed  CAS  Google Scholar 

  63. Chapman, T.J., Castrucci, M.R., Padrick, R.C., Bradley, L.M., and Topham, D.J. 2005, Virology, 340, 296.

    PubMed  CAS  Google Scholar 

  64. Mozdzanowska, K., Furchner, M., Maiese, K., and Gerhard, W. 1997, Virology, 239, 217.

    PubMed  CAS  Google Scholar 

  65. Topham, D.J., and Doherty, P.C. 1998, J Virol, 72, 882.

    PubMed  CAS  Google Scholar 

  66. Lee, B.O., Rangel-Moreno, J., Moyron-Quiroz, J.E., Hartson, L., Makris, M., Sprague, F., Lund, F.E., and Randall, T.D. 2005, J Immunol, 175, 5827.

    PubMed  CAS  Google Scholar 

  67. Sangster, M.Y., Riberdy, J.M., Gonzalez, M., Topham, D.J., Baumgarth, N., and Doherty, P.C. 2003, J Exp Med, 198, 1011.

    PubMed  CAS  Google Scholar 

  68. Topham, D.J., Tripp, R.A., Hamilton-Easton, A.M., Sarawar, S.R., and Doherty, P.C. 1996, J Immunol, 157, 2947.

    PubMed  CAS  Google Scholar 

  69. Swain, S.L., Agrewala, J.N., Brown, D.M., Jelley-Gibbs, D.M., Golech, S., Huston, G., Jones, S.C., Kamperschroer, C., Lee, W.H., McKinstry, K.K., Roman, E., Strutt, T., and Weng, N.P. 2006, Immunol Rev, 211, 8.

    PubMed  CAS  Google Scholar 

  70. Carding, S.R., Allan, W., McMickle, A., and Doherty, P.C. 1993, J Exp Med, 177, 475.

    PubMed  CAS  Google Scholar 

  71. Eichelberger, M.C., Bauchiero, S., Point, D., Richter, B.W., Prince, G.A., and Schuman, R. 2006, Cell Immunol, 243, 67.

    PubMed  CAS  Google Scholar 

  72. Hamilton-Easton, A., and Eichelberger, M. 1995, J Virol, 69, 6359.

    PubMed  CAS  Google Scholar 

  73. Webby, R.J., Andreansky, S., Stambas, J., Rehg, J.E., Webster, R.G., Doherty, P.C., and Turner, S.J. 2003, Proc Natl Acad Sci USA, 100, 7235.

    Google Scholar 

  74. Topham, D.J., Tripp, R.A., and Doherty, P.C. 1997, J Immunol, 159, 5197.

    PubMed  CAS  Google Scholar 

  75. Nguyen, H.H., Moldoveanu, Z., Novak, M.J., van Ginkel, F.W., Ban, E., Kiyono, H., McGhee, J.R., and Mestecky, J. 1999, Virology, 254, 50.

    PubMed  CAS  Google Scholar 

  76. Topham, D.J., Castrucci, M.R., Wingo, F.S., Belz, G.T., and Doherty, P.C. 2001, J Immunol, 167, 6983.

    PubMed  CAS  Google Scholar 

  77. Turner, S.J., Diaz, G., Cross, R., and Doherty, P.C. 2003, Immunity, 18, 549.

    PubMed  CAS  Google Scholar 

  78. Turner, S.J., Cross, R., Xie, W., and Doherty, P.C. 2001, J Immunol, 167, 2753.

    PubMed  CAS  Google Scholar 

  79. Crowe, S.R., Turner, S.J., Miller, S.C., Roberts, A.D., Rappolo, R.A., Doherty, P.C., Ely, K.H., and Woodland, D.L. 2003, J Exp Med, 198, 399.

    PubMed  CAS  Google Scholar 

  80. Jenkins, M.R., Webby, R., Doherty, P.C., and Turner, S.J. 2006, J Immunol, 177, 2917.

    PubMed  CAS  Google Scholar 

  81. Liu, H., Andreansky, S., Diaz, G., Turner, S.J., Wodarz, D., and Doherty, P.C. 2003, J Virol, 77, 7756.

    PubMed  CAS  Google Scholar 

  82. Tripp, R.A., Topham, D.J., Watson, S.R., and Doherty, P.C. 1997, J Immunol, 158, 3716.

    PubMed  CAS  Google Scholar 

  83. Marshall, D.R., Olivas, E., Andreansky, S., La Gruta, N.L., Neale, G.A., Gutierrez, A.,Wichlan, D.G., Wingo, S., Cheng, C., Doherty, P.C., and Turner, S.J. 2005, Proc Natl Acad Sci USA, 102, 6074.

    PubMed  CAS  Google Scholar 

  84. La Gruta, N.L., Turner, S.J., and Doherty, P.C. 2004, J Immunol, 172, 5553.

    PubMed  Google Scholar 

  85. He, X.S., Holmes, T.H., Zhang, C., Mahmood, K., Kemble, G.W., Lewis, D.B., Dekker, C.L., Greenberg, H.B., and Arvin, A.M. 2006, J Virol, 80, 11756.

    PubMed  CAS  Google Scholar 

  86. Ray, S.J., Franki, S.N., Pierce, R.H., Dimitrova, S., Koteliansky, V., Sprague, A.G.,Doherty, P.C., de Fougerolles, A.R., and Topham, D.J. 2004, Immunity, 20, 167.

    PubMed  CAS  Google Scholar 

  87. Epstein, S.L., Lo, C.Y., Misplon, J.A., and Bennink, J.R. 1998, J Immunol, 160, 322.

    PubMed  CAS  Google Scholar 

  88. Harada, Y., Muramatsu, M., Shibata, T., Honjo, T., and Kuroda, K. 2003, J Exp Med, 197, 1779.

    PubMed  CAS  Google Scholar 

  89. Baumgarth, N., Tung, J.W., and Herzenberg, L.A. 2005, Springer Semin Immunopathol, 26, 347.

    PubMed  CAS  Google Scholar 

  90. Doucett, V.P., Gerhard, W., Owler, K., Curry, D., Brown, L., and Baumgarth, N. 2005,J Immunol Methods, 303, 40.

    Google Scholar 

  91. Borrow, P., Hou, S., Gloster, S., Ashton, M., and Hyland, L. 2005, Eur J Immunol, 35, 524.

    PubMed  CAS  Google Scholar 

  92. Mbawuike, I.N., Pacheco, S., Acuna, C.L., Switzer, K.C., Zhang, Y., and Harriman, G.R. 1999, J Immunol, 162, 2530.

    PubMed  CAS  Google Scholar 

  93. Ghendon, Y. 1989, Adv Exp Med Biol, 257, 37.

    PubMed  CAS  Google Scholar 

  94. Riddiough, M.A., Sisk, J.E., and Bell, J.C. 1983, JAMA, 249, 3189.

    PubMed  CAS  Google Scholar 

  95. Clements, M.L., and Stephens, I. 1997, New Generation Vaccines, M.M. Levine, G.C. Woodrow, J.B. Kaper and G.S. Cobon (Eds.), Marcel Dekker, Inc., New York, 545.

    Google Scholar 

  96. Hoskins, T.W., Davies, J.R., Smith, A.J., Miller, C.L., and Allchin, A. 1979, Lancet, 1, 33.

    PubMed  CAS  Google Scholar 

  97. Patriarca, P.A., Weber, J.A., Parker, R.A., Hall, W.N., Kendal, A.P., Bregman, D.J., and Schonberger, L.B. 1985, JAMA, 253, 1136.

    PubMed  CAS  Google Scholar 

  98. Bender, B.S., Johnson, M.P., and Small, P.A. 1991, Immunology, 72, 514.

    PubMed  CAS  Google Scholar 

  99. Renegar, K.B., and Small, P.A., Jr. 1991, J Virol, 65, 2146.

    PubMed  CAS  Google Scholar 

  100. de Haan, A., Geerligs, H.J., Huchshorn, J.P., van Scharrenburg, G.J., Palache, A.M., and Wilschut, J. 1995, Vaccine, 13, 155.

    PubMed  Google Scholar 

  101. Oh, Y., Ohta, K., Kuno-Sakai, H., Kim, R., and Kimura, M. 1992, Vaccine, 10, 506.

    PubMed  CAS  Google Scholar 

  102. Waldman, R.H., Wood, S.H., Torres, E.J., and Small, P.A., Jr. 1970, Am J Epidemiol, 91, 574.

    PubMed  CAS  Google Scholar 

  103. Bizanov, G., Janakova, L., Knapstad, S.E., Karlstad, T., Bakke, H., Haugen, I.L., Haugan, A., Samdal, H.H., and Haneberg, B. 2005, Scand J Immunol, 61, 503.

    PubMed  CAS  Google Scholar 

  104. Plante, M., Jones, T., Allard, F., Torossian, K., Gauthier, J., St-Felix, N., White, G.L.,Lowell, G.H., and Burt, D.S. 2001, Vaccine, 20, 218.

    PubMed  CAS  Google Scholar 

  105. Verweij, W.R., de Haan, L., Holtrop, M., Agsteribbe, E., Brands, R., van Scharrenburg, G.J., and Wilschut, J. 1998, Vaccine, 16, 2069.

    PubMed  CAS  Google Scholar 

  106. Haan, L., Verweij, W.R., Holtrop, M., Brands, R., van Scharrenburg, G.J., Palache, A.M., Agsteribbe, E., and Wilschut, J. 2001, Vaccine, 19, 2898.

    PubMed  CAS  Google Scholar 

  107. Peppoloni, S., Ruggiero, P., Contorni, M., Morandi, M., Pizza, M., Rappuoli, R., Podda, A., and Del Giudice, G. 2003, Expert Review Vaccines, 2, 285.

    CAS  Google Scholar 

  108. Vajdy, M., Singh, M., Ugozzoli, M., Briones, M., Soenawan, E., Cuadra, L., Kazzaz, J., Ruggiero, P., Peppoloni, S., Norelli, F., del Giudice, G., and O’Hagan, D. 2003, Immunology, 110, 86.

    PubMed  CAS  Google Scholar 

  109. Vajdy, M., Singh, M., Kazzaz, J., Soenawan, E., Ugozzoli, M., Zhou, F., Srivastava, I., Bin, Q., Barnett, S., Donnelly, J., Luciw, P., Lourdes, L., Montefiori, D., and O’Hagan, D. 2004, AIDS Res Hum Retroviruses, 20, 1269.

    PubMed  CAS  Google Scholar 

  110. Oh, Y.K., Kim, J.P., Hwang, T.S., Ko, J.J., Kim, J.M., Yang, J.S., and Kim, C.K. 2001, Vaccine, 19, 4519.

    PubMed  CAS  Google Scholar 

  111. Hagiwara, Y., McGhee, J.R., Fujihashi, K., Kobayashi, R., Yoshino, N., Kataoka, K., Etani, Y., Kweon, M.N., Tamura, S., Kurata, T., Takeda, Y., Kiyono, H., Walter, B.A., Valera, V.A., Takahashi, S., and Ushiki, T. 2003, J Immunol, 170, 1754.

    PubMed  CAS  Google Scholar 

  112. Valosky, J., Hishiki, H., Zaoutis, T.E., and Coffin, S.E. 2005, Clin Diagn Lab Immunol, 12, 171.

    PubMed  CAS  Google Scholar 

  113. Walter, B.A., Valera, V.A., Takahashi, S., and Ushiki, T. 2006, Neuropathol Appl Neurobiol, 32, 388.

    PubMed  CAS  Google Scholar 

  114. Vajdy, M., Baudner, B., Del Giudice, G., and O’Hagan, D. 2007, Clin Immunol, 123, 166.

    PubMed  CAS  Google Scholar 

  115. Couch, R.B. 2004, N Engl J Med, 350, 860.

    PubMed  CAS  Google Scholar 

  116. Fiers, W., De Filette, M., Birkett, A., Neirynck, S., and Min Jou, W. 2004, Virus Res, 103, 173.

    PubMed  CAS  Google Scholar 

  117. Ulmer, J.B. 2002, Vaccine, 20, S74.

    PubMed  CAS  Google Scholar 

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  1. School of Medicine, Department of Medical Microbiology and Immunology, University of California, Davis, Davis CA 95616, USA

    Michael Vajdy

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  1. Michael Vajdy
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  1. Davis School of Medicine Department of Medical Microbiology and Immunology, University of California, Davis CA 95616, USA

    Michael Vajdy

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© 2008 Springer Science+Business Media B.V.

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Vajdy, M. (2008). Influenza Virus Pathogenesis and Vaccines. In: Vajdy, M. (eds) Immunity Against Mucosal Pathogens. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-8412-6_15

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