Postprandial Events as a Trigger for Redox Unbalance: Role of Dietary Lipid Hydroperoxides and Antioxidants

  • Fausta Natella
  • Arianna Ramberti
  • Cristina Scaccini

In the late ‘70s Zilversmit hypothesized that the dramatic postprandial modification of the plasma lipid pattern could have a significant effect on atherogenesis. Since then, several evidence has been collected, and it has been demonstrated that many events happening during the postprandial phase, such as oxidative stress and inflammation, are strongly linked to atherosclerosis.

At the moment, there is clear scientific evidence that during the postprandial phase there is an impairment of the redox status (postprandial oxidative stress) that could be determined by (1) the aspecific intake of macronutrients, whose catabolism can lead to the production of oxygen-radical species, or (2) the intake of oxidized/ prooxidant species, which, when absorbed, can directly modify the redox balance.

Thus eating regular meals throughout the day can result in a constant oxidative condition that depends on the relative intake of oxidizable or oxidized nutrients and that of antioxidants. This chapter will focus on the role of dietary lipid hydroper oxides and antioxidants in determining the extent of postprandial oxidative stress.

Keywords

Atherosclerosis oxidative stress antioxidant postprandial phase 

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References

  1. Albrink, MJ and Man, EB (1959). “Serum triglycerides in coronary artery disease.” AMA Arch Intern Med 103(1): 4–8.PubMedGoogle Scholar
  2. Appelt, LC and Reicks, MM (1999). “Soy induces phase II enzymes but does not inhibit dimethylbenz[a]anthracene-induced carcinogenesis in female rats.” J Nutr 129(10): 1820–1826.PubMedGoogle Scholar
  3. Bjorkhem, I and Diczfalusy, U (2002). “Oxysterols: friends, foes, or just fellow passengers?” Arterioscler Thromb Vasc Biol 22(5): 734–742.PubMedCrossRefGoogle Scholar
  4. Blanco-Colio, LM, Valderrama, M, Alvarez-Sala, LA, Bustos, C, Ortego, M, Hernandez-Presa, MA, Cancelas, P, Gomez-Gerique, J, Millan, J and Egido, J (2000). “Red wine intake prevents nuclear factor-kappaB activation in peripheral blood mononuclear cells of healthy volunteers during postprandial lipemia.” Circulation 102(9): 1020–1026.PubMedGoogle Scholar
  5. Cai, Q and Wei, H (1996). “Effect of dietary genistein on antioxidant enzyme activities in SENCAR mice.” Nutr Cancer 25(1): 1–7.PubMedCrossRefGoogle Scholar
  6. Ceriello, A, Bortolotti, N, Motz, E, Crescentini, A, Lizzio, S, Russo, A, Tonutti, L and Taboga, C (1998). “Meal-generated oxidative stress in type 2 diabetic patients.” Diabetes Care 21(9): 1529–1533.PubMedCrossRefGoogle Scholar
  7. Cohn, JS (1998). “Postprandial lipemia: emerging evidence for atherogenicity of remnant lipoproteins.” Can J Cardiol 14 Suppl B: 18B–27B.PubMedGoogle Scholar
  8. Demuth, K, Myara, I, Chappey, B, Vedie, B, Pech-Amsellem, MA, Haberland, ME and Moatti, N (1996). “A cytotoxic electronegative LDL subfraction is present in human plasma.” Arterioscler Thromb Vasc Biol 16(6): 773–783.PubMedGoogle Scholar
  9. Ebenbichler, CF, Kirchmair, R, Egger, C and Patsch, JR (1995). “Postprandial state and atherosclerosis.” Curr Opin Lipidol 6(5): 286–290.PubMedCrossRefGoogle Scholar
  10. Esposito, K, Nappo, F, Giugliano, F, Giugliano, G, Marfella, R and Giugliano, D (2003). “Effect of dietary antioxidants on postprandial endothelial dysfunction induced by a high-fat meal in healthy subjects.” Am J Clin Nutr 77(1): 139–143.PubMedGoogle Scholar
  11. Floren, CH and Chait, A (1981). “Uptake of chylomicron remnants by the native LDL receptor in human monocyte-derived macrophages.” Biochim Biophys Acta 665(3): 608–611.PubMedGoogle Scholar
  12. Frankel, EN (1984). “Chemistry of free radical and singlet oxidation of lipids.” Prog Lipid Res 23(4): 197–221.PubMedCrossRefGoogle Scholar
  13. Fuhrman, B, Brook, JG and Aviram, M (1986). “Increased platelet aggregation during alimentary hyperlipemia in normal and hypertriglyceridemic subjects.” Ann Nutr Metab 30(4): 250–260.PubMedCrossRefGoogle Scholar
  14. Ginsberg, HN, Karmally, W, Siddiqui, M, Holleran, S, Tall, AR, Blaner, WS and Ramakrishnan, R (1995). “Increases in dietary cholesterol are associated with modest increases in both LDL and HDL cholesterol in healthy young women.” Arterioscler Thromb Vasc Biol 15(2): 169–178.PubMedGoogle Scholar
  15. Gorelik, S, Lapidot, T, Shaham, I, Granit, R, Ligumsky, M, Kohen, R and Kanner, J (2005). “Lipid peroxidation and coupled vitamin oxidation in simulated and human gastric fluid inhibited by dietary polyphenols: health implications.” J Agric Food Chem 53(9): 3397–3402.PubMedCrossRefGoogle Scholar
  16. Grootveld, M, Atherton, MD, Sheerin, AN, Hawkes, J, Blake, DR, Richens, TE, Silwood, CJ, Lynch, E and Claxson, AW (1998). “In vivo absorption, metabolism, and urinary excretion of alpha, beta-unsaturated aldehydes in experimental animals. Relevance to the development of cardiovascular diseases by the dietary ingestion of thermally stressed polyunsaturate-rich culinary oils.” J Clin Invest 101(6): 1210–1218.PubMedCrossRefGoogle Scholar
  17. Halliwell, B, Zhao, K and Whiteman, M (2000). “The gastrointestinal tract: a major site of antioxidant action?” Free Radic Res 33(6): 819–830.PubMedCrossRefGoogle Scholar
  18. Huff, MW (2003). “Dietary cholesterol, cholesterol absorption, postprandial lipemia and atherosclerosis.” Can J Clin Pharmacol 10 Suppl A: 26A–32A.PubMedGoogle Scholar
  19. Hurst, R, Bao, Y, Jemth, P, Mannervik, B and Williamson, G (1998). “Phospholipid hydroperoxide glutathione peroxidase activity of human glutathione transferases.” Biochem J 332(Pt 1): 97–100.PubMedGoogle Scholar
  20. Kaminsky, LS and Zhang, QY (2003). “The small intestine as a xenobiotic-metabolizing organ.” Drug Metab Dispos 31(12): 1520–1525.PubMedCrossRefGoogle Scholar
  21. Kanner, J and Lapidot, T (2001). “The stomach as a bioreactor: dietary lipid peroxidation in the gastric fluid and the effects of plant-derived antioxidants.” Free Radic Biol Med 31(11): 1388–1395.PubMedCrossRefGoogle Scholar
  22. Karpe, F, Steiner, G, Uffelman, K, Olivecrona, T and Hamsten, A (1994). “Postprandial lipoproteins and progression of coronary atherosclerosis.” Atherosclerosis 106(1): 83–97.PubMedCrossRefGoogle Scholar
  23. Kugiyama, K, Doi, H, Takazoe, K, Kawano, H, Soejima, H, Mizuno, Y, Tsunoda, R, Sakamoto, T, Nakano, T, Nakajima, K, Ogawa, H, Sugiyama, S, Yoshimura, M and Yasue, H (1999). “Remnant lipoprotein levels in fasting serum predict coronary events in patients with coronary artery disease.” Circulation 99(22): 2858–2860.PubMedGoogle Scholar
  24. Lechleitner, M, Hoppichler, F, Foger, B and Patsch, JR (1994). “Low-density lipoproteins of the postprandial state induce cellular cholesteryl ester accumulation in macrophages.” Arterioscler Thromb 14(11): 1799–1807.PubMedGoogle Scholar
  25. Leonarduzzi, G, Sottero, B and Poli, G (2002). “Oxidized products of cholesterol: dietary and metabolic origin, and proatherosclerotic effects (review).” J Nutr Biochem 13(12): 700–710.PubMedCrossRefGoogle Scholar
  26. Liska, DJ (1998). “The detoxification enzyme systems.” Altern Med Rev 3(3): 187–198.PubMedGoogle Scholar
  27. Marfella, R, Quagliaro, L, Nappo, F, Ceriello, A and Giugliano, D (2001). “Acute hyperglycemia induces an oxidative stress in healthy subjects.” J Clin Invest 108(4): 635–636.PubMedGoogle Scholar
  28. Moon, YJ, Wang, X and Morris, ME (2006). “Dietary flavonoids: effects on xenobiotic and carcinogen metabolism.” Toxicol In Vitro 20(2): 187–210.PubMedCrossRefGoogle Scholar
  29. Moro, E, Zambon, C, Pianetti, S, Cazzolato, G, Pais, M and Bittolo_Bon, G (1998). “Electronegative low density lipoprotein subform (LDL-) is increased in type 2 (non-insulin-dependent) microalbuminuric diabetic patients and is closely associated with LDL susceptibility to oxidation.” Acta Diabetologica 35(3): 161–164.PubMedCrossRefGoogle Scholar
  30. Mutanen, M and Freese, R (2001). “Fats, lipids and blood coagulation.” Curr Opin Lipidol 12(1): 25–29.PubMedCrossRefGoogle Scholar
  31. Nappo, F, Esposito, K, Cioffi, M, Giugliano, G, Molinari, AM, Paolisso, G, Marfella, R and Giugliano, D (2002). “Postprandial endothelial activation in healthy subjects and in type 2 diabetic patients: role of fat and carbohydrate meals.” J Am Coll Cardiol 39(7): 1145–1150.PubMedCrossRefGoogle Scholar
  32. Naruszewicz, M, Wozny, E, Mirkiewicz, E, Nowicka, G and Szostak, WB (1987). “The effect of thermally oxidized soya bean oil on metabolism of chylomicrons. Increased uptake and degradation of oxidized chylomicrons in cultured mouse macrophages.” Atherosclerosis 66(1–2): 45–53.PubMedCrossRefGoogle Scholar
  33. Natella, F, Belelli, F, Gentili, V, Ursini, F and Scaccini, C (2002). “Grape seed proanthocyanidins prevent plasma postprandial oxidative stress in humans.” J Agric Food Chem 50(26): 7720–7725.PubMedCrossRefGoogle Scholar
  34. Natella, F, Fidale, M, Tubaro, F, Ursini, F and Scaccini, C (2007). “Selenium supplementation prevents the increase in atherogenic electronegative LDL (LDL minus) in the postprandial phase.” Nutr Metab Cardiovasc Dis 17(9):649–656.PubMedCrossRefGoogle Scholar
  35. Natella, F, Ghiselli, A, Guidi, A, Ursini, F and Scaccini, C (2001). “Red wine mitigates the postprandial increase of LDL susceptibility to oxidation.” Free Radic Biol Med 30(9): 1036–1044.PubMedCrossRefGoogle Scholar
  36. Patsch, JR, Miesenbock, G, Hopferwieser, T, Muhlberger, V, Knapp, E, Dunn, JK, Gotto, AM, Jr. and Patsch, W (1992). “Relation of triglyceride metabolism and coronary artery disease. Studies in the postprandial state.” Arterioscler Thromb 12(11): 1336–1345.PubMedGoogle Scholar
  37. Phillips, NR, Waters, D and Havel, RJ (1993). “Plasma lipoproteins and progression of coronary artery disease evaluated by angiography and clinical events.” Circulation 88(6): 2762–2770.PubMedGoogle Scholar
  38. Plotnick, GD, Corretti, MC and Vogel, RA (1997). “Effect of antioxidant vitamins on the transient impairment of endothelium-dependent brachial artery vasoactivity following a single high-fat meal.” JAMA 278(20): 1682–1686.PubMedCrossRefGoogle Scholar
  39. Sanchez_Quesada, JL, Camacho, M, Anton, R, Benitez, S, Vila, L and Ordonez_Llanos, J (2003). “Electronegative LDL of FH subjects: chemical characterization and induction of chemokine release from human endothelial cells.” Atherosclerosis 166(2): 261–270.PubMedCrossRefGoogle Scholar
  40. Sesink, AL, Termont, DS, Kleibeuker, JH and Van der Meer, R (1999). “Red meat and colon cancer: the cytotoxic and hyperproliferative effects of dietary heme.” Cancer Res 59(22): 5704–5709.PubMedGoogle Scholar
  41. Sevanian, A, Hwang, J, Hodis, H, Cazzolato, G, Avogaro, P and Bittolo-Bon, G (1996). “Contribution of an in vivo oxidized LDL to LDL oxidation and its association with dense LDL subpopulations.” Arterioscler Thromb Vasc Biol 16(6): 784–793.PubMedGoogle Scholar
  42. Sies, H, Stahl, W and Sevanian, A (2005). “Nutritional, dietary and postprandial oxidative stress.” J Nutr 135(5): 969–972.PubMedGoogle Scholar
  43. Staprans, I, Pan, XM, Miller, M and Rapp, JH (1993). “Effect of dietary lipid peroxides on metabolism of serum chylomicrons in rats.” Am J Physiol 264(3 Pt 1): G561–G568.PubMedGoogle Scholar
  44. Staprans, I, Pan, XM, Rapp, JH and Feingold, KR (1998). “Oxidized cholesterol in the diet accelerates the development of aortic atherosclerosis in cholesterol-fed rabbits.” Arterioscler Thromb Vasc Biol 18(6): 977–983.PubMedGoogle Scholar
  45. Staprans, I, Pan, XM, Rapp, JH and Feingold, KR (2003). “Oxidized cholesterol in the diet is a source of oxidized lipoproteins in human serum.” J Lipid Res 44(4): 705–715.PubMedCrossRefGoogle Scholar
  46. Staprans, I, Pan, XM, Rapp, JH, Grunfeld, C and Feingold, KR (2000). “Oxidized cholesterol in the diet accelerates the development of atherosclerosis in LDL receptor- and apolipoprotein E-deficient mice.” Arterioscler Thromb Vasc Biol 20(3): 708–714.PubMedGoogle Scholar
  47. Staprans, I, Rapp, JH, Pan, XM and Feingold, KR (1996). “Oxidized lipids in the diet are incorporated by the liver into very low density lipoprotein in rats.” J Lipid Res 37(2): 420–430.PubMedGoogle Scholar
  48. Sutherland, WH, Walker, RJ, de Jong, SA, van Rij, AM, Phillips, V and Walker, HL (1999). “Reduced postprandial serum paraoxonase activity after a meal rich in used cooking fat.” Arterioscler Thromb Vasc Biol 19(5): 1340–1347.PubMedGoogle Scholar
  49. Terao, J, Ingemansson, T, Ioku, K, Yuki, H and Ito, Y (1995). “Effects of rat bile-pancreatic juice on Fe2 + induced peroxidation of phospholipids.” Biosci Biotechnol Biochem 59(1): 55–58.PubMedCrossRefGoogle Scholar
  50. Twickler, TB, Dallinga-Thie, GM, Visseren, FL, de Vries, WR, Erkelens, DW and Koppeschaar, HP (2003). “Induction of postprandial inflammatory response in adult onset growth hormone deficiency is related to plasma remnant-like particle-cholesterol concentration.” J Clin Endocrinol Metab 88(3): 1228–1233.PubMedCrossRefGoogle Scholar
  51. Ursini, F and Sevanian, A (2002a). “Postprandial oxidative stress.” Biol Chem 383(3–4): 599–605.PubMedCrossRefGoogle Scholar
  52. Ursini, F and Sevanian, A (2002b). “Wine polyphenols and optimal nutrition.” Ann NY Acad Sci 957: 200–209.PubMedCrossRefGoogle Scholar
  53. Ursini, F, Zamburlini, A, Cazzolato, G, Maiorino, M, Bon, GB and Sevanian, A (1998). “Postprandial plasma lipid hydroperoxides: a possible link between diet and atherosclerosis.” Free Radic Biol Med 25(2): 250–252.PubMedCrossRefGoogle Scholar
  54. van de Bovenkamp, P, Kosmeijer-Schuil, TG and Katan, MB (1988). “Quantification of oxysterols in Dutch foods: egg products and mixed diets.” Lipids 23(11): 1079–1085.PubMedCrossRefGoogle Scholar
  55. van der Logt, EM, Roelofs, HM, Nagengast, FM and Peters, WH (2003). “Induction of rat hepatic and intestinal UDP-glucuronosyltransferases by naturally occurring dietary anticarcinogens.” Carcinogenesis 24(10): 1651–1656.PubMedCrossRefGoogle Scholar
  56. Van Lenten, BJ, Fogelman, AM, Jackson, RL, Shapiro, S, Haberland, ME and Edwards, PA (1985). “Receptor-mediated uptake of remnant lipoproteins by cholesterol-loaded human monocyte-macrophages.” J Biol Chem 260(15): 8783–8788.PubMedGoogle Scholar
  57. van Oostrom, AJ, Rabelink, TJ, Verseyden, C, Sijmonsma, TP, Plokker, HW, De Jaegere, PP and Cabezas, MC (2004). “Activation of leukocytes by postprandial lipemia in healthy volunteers.” Atherosclerosis 177(1): 175–182.PubMedCrossRefGoogle Scholar
  58. van Oostrom, AJ, Sijmonsma, TP, Verseyden, C, Jansen, EH, de Koning, EJ, Rabelink, TJ and Castro Cabezas, M (2003). “Postprandial recruitment of neutrophils may contribute to endothelial dysfunction.” J Lipid Res 44(3): 576–583.PubMedCrossRefGoogle Scholar
  59. Vine, DF, Croft, KD, Beilin, LJ and Mamo, JC (1997). “Absorption of dietary cholesterol oxidation products and incorporation into rat lymph chylomicrons.” Lipids 32(8): 887–893.PubMedCrossRefGoogle Scholar
  60. Vogel, RA, Corretti, MC and Plotnick, GD (1997). “Effect of a single high-fat meal on endothelial function in healthy subjects.” Am J Cardiol 79(3): 350–354.PubMedCrossRefGoogle Scholar
  61. Williams, MJ, Sutherland, WH, McCormick, MP, de Jong, SA, Walker, RJ and Wilkins, GT (1999). “Impaired endothelial function following a meal rich in used cooking fat.” J Am Coll Cardiol 33(4): 1050–1055.PubMedCrossRefGoogle Scholar
  62. Wolff, SP and Nourooz-Zadeh, J (1996). “Hypothesis: UK consumption of dietary lipid hydroperoxides–a possible contributory factor to atherosclerosis.” Atherosclerosis 119(2): 261–263.PubMedCrossRefGoogle Scholar
  63. Yagi, K, Kiuchi, K, Saito, Y, Miike, A, Kayahara, N, Tatano, T and Ohishi, N (1986). “Use of a new methylene blue derivative for determination of lipid peroxides in foods.” Biochem Int 12(2): 367–371.PubMedGoogle Scholar
  64. Zilversmit, DB (1979). “Atherogenesis: a postprandial phenomenon.” Circulation 60(3): 473–485.PubMedGoogle Scholar
  65. Ziouzenkova, O, Asatryan, L and Sevanian, A (1999). “Oxidative stress resulting from hemolysis and formation of catalytically active hemoglobin: protective strategies.” Int J Clin Pharmacol Ther 37(3): 125–132.PubMedGoogle Scholar

Copyright information

© Springer Science + Business Media B.V 2008

Authors and Affiliations

  • Fausta Natella
    • 1
  • Arianna Ramberti
    • 1
  • Cristina Scaccini
    • 1
  1. 1.National Research Institute for Food and NutritionItaly

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