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Functions of Autocrine Motility Factor at the Tumor Microenvironment

  • Chapter
Regulation of Gene Expression in the Tumor Environment

Part of the book series: TTME ((TTME,volume 2))

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Autocrine motility factor (AMF) is a tumor-secreted cytokine and is abundant at tumor sites, where it may affect the process of tumor growth and metastasis. AMF is a multifunctional protein capable of affecting cell migration, invasion, proliferation, and survival, and possesses phosphoglucose isomerase activity and can catalyze the step in glycolysis and gluconeogenesis. Here, we review the role of AMF and tumor environment on malignant processes. The outcome of metastasis depends on multiple interactions between tumor cells and homeostatic mechanisms; therefore elucidation of the tumor/host interactions in the tumor microenvironment is essential in the development of new prevention and treatment strategies. Such knowledge might provide clues to develop new future therapeutic approaches for human cancers.

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  1. Tumor Progression and Metastasis Program, Barbara Ann Karmanos Cancer Institute Wayne State University School of Medicine, Detroit, MI 48201, USA

    Avraham Raz

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  1. Tatsuyoshi Funasaka
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  2. Avraham Raz
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  1. Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA

    Menashe Bar-Eli (Dr) (Dr)

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Funasaka, T., Raz, A. (2008). Functions of Autocrine Motility Factor at the Tumor Microenvironment. In: Bar-Eli, M. (eds) Regulation of Gene Expression in the Tumor Environment. TTME, vol 2. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-8341-9_2

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