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Functions of Autocrine Motility Factor at the Tumor Microenvironment

  • Tatsuyoshi Funasaka
  • Avraham Raz
Part of the TTME book series (TTME, volume 2)

Autocrine motility factor (AMF) is a tumor-secreted cytokine and is abundant at tumor sites, where it may affect the process of tumor growth and metastasis. AMF is a multifunctional protein capable of affecting cell migration, invasion, proliferation, and survival, and possesses phosphoglucose isomerase activity and can catalyze the step in glycolysis and gluconeogenesis. Here, we review the role of AMF and tumor environment on malignant processes. The outcome of metastasis depends on multiple interactions between tumor cells and homeostatic mechanisms; therefore elucidation of the tumor/host interactions in the tumor microenvironment is essential in the development of new prevention and treatment strategies. Such knowledge might provide clues to develop new future therapeutic approaches for human cancers.

Keywords

Motility factor Autocrine effect Survival Apoptosis Tumor-host interaction Extracellular matrix Collagen Cytokines 

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Copyright information

© Springer Science+Business Media B.V. 2008

Authors and Affiliations

  • Tatsuyoshi Funasaka
  • Avraham Raz
    • 1
  1. 1.Tumor Progression and Metastasis Program, Barbara Ann Karmanos Cancer Institute Wayne State University School of MedicineDetroitUSA

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