Debaryomyces hansenii (teleomorph of asporogenous strains known as Candida famata ) belongs to the group of so named ‘ flavinogenic yeasts ’ capable of riboflavin oversynthesis during starvation for iron. Some strains of C. famata belong to the most flavinogenic organisms known (accumulate 20 mg of riboflavin in 1 ml of the medium) and were used for industrial production of riboflavin in USA for long time. Many strains of D. hansenii are characterized by high salt tolerance and are used for ageing of cheeses whereas some others are able to convert xylose to xylitol, anti-caries sweetener. Transformation system has been developed for D. hansenii. It includes collection of host recipient strains, vectors with complementation and dominant markers and several transformation protocols based on protoplasting and electroporation. Besides, methods of multicopy gene insertion and insertional mutagenesis have been developed and several strong constitutive and regulatable promoters have been cloned. All structural genes of riboflavin synthesis and some regulatory genes involved in this process have been identified. Genome of D. hansenii has been sequenced in the frame of French National program ‘Genolevure’ and is opened for public access
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Abbas, C., Voronovsky, A.Y., Fayura, L.R., Kshanovska, B.V., Dmytruk, K.V., Sibirna, K.A. and Sibirny, A.A. 2006. US Patent No 7009045.
Adler, L., Blomberg A., and Nilsson, A. 1985. J. Bacteriol. 162: 300–306.
Ahmed, Z., Sasahara H., Bhuiyan, S.H., Saiki, T., Shimonishi, T., Takada, G. and Izumori, K. 1999.J. Biosci. Bioeng. 88: 676–678.
Alba-Lois, L., Segal C., Rodarte,h B., Valdes-Lopez, V., DeLuna, A. and Cardenas, R. 2004. Curr.Microbiol. 48: 68–72.
Almagro, A., Prista, C., Benito B., Loureiro-Dias, M.C. and Ramos, J. 2001. J. Bacteriol. 183:3251–3255.
Andre, L., Hemming, A. and Adler, L. 1991. FEBS Lett. 286: 1–17.
Arfi, K., Spinnle, H.E., Tache, R., and Bonnarme, P. 2002. Appl. Microbiol. Biotechnol. 58:503–510.
Barbosa, M.F.S., Medeiros, M.B., de Mancilha, I.M., Schneider, H. and Lee, H. 1988. J. Ind.Microbiol. 3: 241–251.
Becker, D.M. and Guarente, L. 1991. High efficiency transformation of yeast by electroporation.In: Guide to yeast genetics and molecular biology - Methods in Enzymology,Guithrie C. Fink G.R. (Eds.), Vol. 194, Academic Press Inc, San Diego, CA., pp. 182–185.
Besancon, X., Ratomahenina, R. and Galzy, P. 1995. Neth Milk Dairy J. 49: 97–110.
Bolumar, T., Sanz, Y., Aristoy, M.-C. and Toldra, F. 2003a. Appl. Environ. Microbiol. 69:227–232.
Bolumar, T., Sanz, Y., Aristoy, M.-C. and Toldra, F. 2003b. Int. J. Food Microbiol. 86: 141–151.
Bon, E., Casaregola, S., Blandin, G., Llorente, B., Neuvéglise, C., Munsterkotter, M., Guldener, U.,Mewes, H.-W., VanHelden, J., Dujon, B. Gaillardin, C. 2003. Nucleic Acids Res. 31:1121–1135.
Breuer, A. and Harms, H. 2006. Yeast 23: 415–437.
Carreira, A., Paloma, L. and Loureiro, V. 1998. Int. J. Food. Microbiol. 41: 223–230.
Carvalheiro, F., Duarte, L.C., Medeiros, R. and Girio, F. M. 2004. Appl. Biochem. Biotechnol. 113 –116: 1059–1072.
Charoenchai, C., Fleet, G.H., Henschke, P.A. and Todd, B.E.N. 1997. Austr. J. Grape Wine Res. 3:2–8.
Converti, A. and Dominguez, J.M. 2001. Biotechnol. Bioeng. 75: 39–45.
Converti, A., Perego, P. and Dominguez, J.M. 1999. App. Biochem. Biotechnol. 82 : 141–151.
Converti, A., Perego, P., Sordi, A. and Torre, P. 2002. App. Biochem. Biotechnol. 101: 15–29.
Corredor, M., Davila, A.-M., Casaregola, S. and Gaillardin, C. 2003. Antonie van Leeuwenhoek 83: 215–222.
Cowart, R.E., Marquardt, M.P. and Foster, B.G. 1980. Microbiol. Lett. 13: 117–122.
Cruz, J.M., Dominguez, J.M., Dominguez, H. and Parajo, J.C. 2000a. Biotechnol. Lett. 22:605–610.
Cruz, J.M., Dominguez, J.M., Dominguez, H. and Parajo, J.C. 2000b. Biotechnol. Lett. 22: 1895 – 1898.
Dalton, H.K., Board, R.G. and Davenport, R.R. 1984. Antonie van Leeuwenhoek 50: 227–248.
Davenport, R.R. 1980. Cold-tolerant yeasts and yeast-like organisms. In: Biology and activities of yeasts, Skinner F.A., Passmore S.M. Davenport R.R. (Eds.), Academic Press, London, pp. 215–230.
De Faveri, D., Torre, P., Perego, P. and Converti, A. 2004. J Food Eng.65:383–389.
Deiana, P., Fatichenti, F., Farris, G.A., Mocquot, G., Lodi, R., Todesco, R. and Cecchi, L. 1984. Lait 64: 380–394.
van Dijk, R., Faber, K.N., Hammond, A.T., Glick, B.S., Veenhuis, M., and Kiel, J.A.K.W. 2001. Mol. Genet. Genomics 266: 646–656.
Dmytruk, K.V., Abbas, C.A., Voronovsky, A.Y., Kshanovska, B.V., Sybirna, M.C. and Sibirny, A. A. 2004. Ukr. Biokhim. Zh. 76: 78–87.
Dmytruk, K.V., Voronovsky, A.Y. and Sibirny, A.A. 2006. Curr. Genet. 50: 183–191.
Dominguez, J.M. 1998. Biotechnol. Lett. 20: 53–56.
Dujon, B., Sherman, D., Fischer, G., Durrens, P., Casaregola, S., Lafontaine, I., Montigny, J., de Marck, C., Neuveglise, C., Talla, E., Goffard, N., Frangeul, L., Aiglem, M., Anthouard, V., Babour, A., Barbe, V., Barnay, S., Blanchin, S., Beckerich, J.M., Beyne, E., Bleykasten, C., Boisrame, A., Boyer, J., Cattolico L., Confanioleri, F., DeDaruvar, A., Despons, L., Fabre, E., Fairhead, C., Ferry-Dumazet, H., Groppi, A., Hantraye, F., Hennequin, C., Jauniaux, N., Joyet, P., Kachouri, R., Kerrest, A., Koszul, R., Lemaire, M., Lesur, I., Ma, L., Muller, H., Nicaud, J.M., Nikolski, M., Oztas, S., Ozier-Kalogeropoulos, O., Pellenz, S., Potier, S., Richard, G.F., Straub, M.L., Suleau, A., Swennen, D., Tekaia, F., Wesolowski-Louvel, M., Westhof, E., Wirth, B., Zeniou-Meyer, M., Zivanovic, I., Bolotin-Fukuhara, M., Thierry, A., Bouchier, C., Caudron, B., Scarpelli, C., Gaillardin, C., Weissenbach, J., Wincker, P., and Souciet, J.L. 2004. Nature 430: 35–44.
Dura, M.A., Flores, A. and Toldra, F. 2004a. Food Chem. 86 : 385–389.
Dura, M.A., Flores, M. and Toldra, F. 2004b. Food Chem. 86: 391–399.
El Soda, M. 1986. J. Food Prot. 49: 395–399.
Esteve-Zarsoso, B., Manzanares, P., Ramon, D. and Querol, A. 1998. Int. Microbiol. 1 : 143–148.
Faber, K.N., Haima, P., Harder, W., Veenhuis, M. and Ab, G. 1994 Curr. Genet. 25: 305–310.
Fatichenti, F., Bergere, J.L., Deiana, A. and Farris, G.A. 1983. J. Dairy Res. 50: 449–457.
Ferreira, A. and Viljoen, B.C. 2003. Int. J. Food Microbiol. 86: 131–140.
Fitzpatrick, D.A., Logue, M.E., Stajich, J.E. and Butler, G. 2006.BMC Evol. Biol. 6: 99.
Fleet, G.H. 1990. J. Appl. Bacteriol. 68: 199–211.
Fleet, M.C. and Mian, M.A. 1987. Int. J. Food Microbiol. 4: 145–155.
Flores, M., Dura, M.A., Marco, A. and Toldra, F. 2004. Meat Sci. 68: 439–446.
Furlan, S., Bouilloud, P., Strehaiano, P. and Riba, J.P. 1991. Biotechnol. Lett. 13: 203–206.
Gadd, G.M. and Edwards, S.W. 1986. Trans. Br. Mycol. Soc. 87: 533–542.
Garcia-Gonzalez, A. and Ochoa, J.L. 1999. Arch. Med. Res. 30: 69–73.
Girio, F.M., Roseiro, J.C., Sa-Machado, P., Duarte-Reis, A.R. and Amaral-Collaco, M.T. 1994. Enzyme Microb. Technol. 16: 1074–1078.
Glaser, H.U., Thomas, D., Gaxiola, R., Montrichard, F., Surdin-Kerjan, Y. and Serrano, R. 1993. EMBO J. 12: 3105–3110.
Goodwin, T.W. and McEvoy, D. 1959. Biochem. J. 71: 742–748.
Granado, J.D., Kertesz-Chaloupkova, K., Aebi, M. and Kues, U. 1997. Mol. Gen. Genet. 256: 28–36.
Groom, K.R., Heyman, H.C., Steffen, M.C., Hawkins, L. and Martin, N.C. 1998. Yeast 14: 77–87.
Guerzoni, M.E., Lanciotti, A. and Marchetti, R. 1993. Int. J. Food Microbiol. 17: 329–341.
Hansen, T.K., van den Tempel, T., Cantor, M.D. and Jakobsen, M. 2001. Int. J. Food Microbiol. 69: 101–111.
Heefner, D.L., Boyts, A., Burdzinski, L.A. and Yarus, M.J. 1993. US Patent No 5231007.
Heefner, D.L., Weaver, C.A., Yarus, M.J., and Burdzinski, L.A. 1992. US Patent No 5164303.
Heefner, D.L., Weaver, C.A., Yarus, M.J., Burdzinski, L.A., Gyure, D.C. and Foster, E.W. 1988. Patent WO 88/09822.
Hernandez-Saavedra, N.Y. and Romero-Geraldo, R. 2001. Yeast 18: 1227–1238.
Ishchuk, O.P., Dmytruk, K.V., Rohulya, O.V., Voronovsky, A.Y., Abbas, C.A. and Sibirny, A.A.2008. Enz. Microb. Technol. 42: 208–215.
Jovall, P.A., Tunblad-Johanson, I. and Adler, L. 1990. Arch. Microbiol. 154: 209–214.
Kang, S.and Metzenberg, R.L. 1993. Genetics 133: 193–202.
Klein, N., Zourari, A. and Lortal, S. 2002. Int. Dairy J. 12: 853–861.
Kreger van Rij, N.J. and Veenhuis, M. 1975. J. Gen. Microbiol. 89: 256–264.
Kumura, H., Takagaki, K., Sone, T., Tsukahara, M., Tanaka, T. and Shimazaki, K. 2002. Biosci.Biotechnol. Biochem. 66: 1370–1373.
Kurtzman, C.P. and Robnett, C.J. 1997. J. Clin. Microbiol. 35: 1216–1223.
Kurtzman, C.P. and Robnett, C.J. 1998. Antonie van Leeuwenhoek 73: 331–371.
Kuspa, A. and Loomis, W.F. 1992. Proc. Natl. Acad. Sci. USA 89: 8803–8807.
Lages, F., Silva-Graca, M. and Lucas, C. 1999. Microbiology 145: 2577–2586.
Langin, T., Faugeron, G., Goyon, C., Nicolas, A. and Rossignol, J.L. 1986. Gene 49: 283–293.
Larsson C., Morales, C., Gustafsson, L. Adler, L. and 1990. J. Bacteriol. 172: 1769–1774.
Leclercq-Perlat, M.-N., Corrieu, G. and Spinnler, H.-E. 2004. J. Dairy Sci. 87: 1545–1550.
Leclercq-Perlat, M.-N., Oumer, A., Buono, F., Bergere, J.L., Spinnler H.E. and Corrieu, G. 2000.J. Dairy Sci. 83: 1674–1683.
Lépingle, A., Casaregola, S., Neuveglise, C., Bon, E., Nguyen, H.-V., Artiguenave, F., Wincker, P.and Gaillardin, C. 2000. FEBS Lett. 487: 82–86.
Levine, H., Oyaas, J.E., Wassermann, L., Hoogerheide, J.C. and Stern, R.M. 1949. Ind. Eng.Chem. 41: 1665–1668.
Li, Y., Chen, J. and Lun, S.Y. 2001. Appl. Microbiol. Biotechnol. 57: 451–459.
Lodder, J. 1970. The Yeasts — A Taxonomic Study, 2nd Edn. Amsterdam.North-Holland.
Lucas, C., da Costa M. and van Uden, N. 1990. Yeast 6: 187–191.
Martin, A., Cordoba, J.J., Nunez, F., Benito, M.J. and Asensio, M.A. 2004. Int. J. Food Microbiol. 94: 55–66
Mayer, G., Kulbe, K.D. and Nidetzky, B. 2002. App. Biochem. Biotechnol. 99: 577–590.
Nakase, T. and Suzuki, M. 1985. J. Gen. Appl. Microbiol. 31: 71–86.
Nakase, T., Suzuki, M., Phaff, H.J. and Kurtzman, C.P. 1998. Debaryomyces Lodder & Kreger-van Rij Nom. Cons. In: The Yeasts — A Taxonomic Study, Kurtzman M.C. Fell J.W. (Eds.),Elsevier, Amsterdam, pp. 157–173.
Neves, M.L., Oliveira, R.P. and Lucas, C. 1997. Microbiology 143: 1133–1139.
Nichol, A.W., Harden, M.C. and Tuckett, W.H. 1996. Food Austral. 48: 136–138.
Nilsson, A. and Adler, L. 1990. Biochim. Biophys. Acta 1034: 180–185.
Nishikawa, A., Tomomatsu, H., Sugita, T., Ikeda, R. and Shinoda, T. 1996. J. Med. Vet. Mycol. 34: 411–419.
Nobre, A., Duarte, L.C., Roseiro, J.C. and Girio, F. M. 2002. Appl. Microbiol. Biotechnol. 59: 509–516.
Nobre, A., Lucas, C. and Leao, C. 1999. Appl. Environ. Microbiol. 65: 3594–3598.
Norkrans, B. 1966. Arch. Mikrobiol. 54: 374–392.
Norkrans, B. 1968. Arch. Mikrobiol. 62: 358–372.
Ochoa, J.L., Ramirez-Orozco, M., Hernandez-Saavedra, N.Y., Hernandez-Saavedra, D. and Sanchez-Paz, A. 1995. J. Mar. Biotechnol. 3: 224–227.
Onishi, H. 1963. Adv. Food Res. 12: 53–94.
Orozco, M.R., Hernandez-Saavedra, N.Y., Valle, F.A., Gonzalez, B.A. and Ochoa, J.L. 1998. J.Mar. Biotechnol. 6: 255–259.
Parajo, J.C., Dominguez, H. and Dominguez, J.M. 1996. Biotechnol. Lett. 18: 593–598.
Parajo, J.C., Dominguez, H. and Dominguez, J.M. 1997. Enz. Microb. Technol. 21: 18–24.
Petersen, K.M. and Jespersen, L. 2004. J. Appl. Microbiol. 97: 205–213.
Prista, C., Almagro, A., Loureiro-Dias, M.C. and Ramos, J. 1997. Appl. Environ. Microbiol. 63: 4005–4009.
Prista, C., Loureiro-Dias, M.C., Montiel, V., Garcia, R. and Ramos, J. 2005. FEMS Yeast Res. 5: 693–701.
Roostita, A. and Fleet, G.H. 1996 Int. J. Food Microbiol. 28: 393–404.
Roseiro, J.C., Peito, M.A., Girio, F.M. and Amaral-Collaco, M.T. 1991. Arch. Microbiol. 156: 484–490
Rowley, A., Dowell, S.J. and Diffley, J.F.X. 1994. Biochim. Biophys. Acta 1217: 239–256.
Saha, B.C. and Bothast, R.J. 1996. Biotechnol. Lett. 18: 155–158.
Saldanha-da-Gama, A., Malfeito-Ferreira, and M. Loureiro, V. 1997. Int. J. Food Microbiol. 37: 201–207.
Schiestl, R.H. and Petes, T.D. 1991. Proc. Natl. Acad. Sci. USA 88: 7585–7589.
Seiler, H. and Busse, M. 1990. Int. J. Food Microbiol. 11: 289–303.
Semon, D., Movva, N., Rao Smith, T.F., Mohamed El Alama, and Davies, J. 1987. Plasmid 17: 46–53.
Shavlovsky, M.C. and Logvinenko, G.M. 1988. Prikl. Biokhim.Mikrobiol. 24: 435–447 (in Russian).
Shavlovsky, G.M., Zharova, V.P., Shchelokova, I.F., Trach, V.M., Sibirny, A.A. and Ksheminskaya,G.P. 1978. Prikl. Biokhim. Mikrobiol. 14: 184–189 (in Russian).
Sibirny, A.A., Fedorovych, D.V., Boretsky, Y.R. and Voronovsky, A.Y. 2006. Microbial synthesis of flavins. Naukova Dumka, Kyiv (Kiev), Ukraine, p. 192 (in Ukrainian).
Sreekrishna, A.and Kropp, K.E. 1996. Pichia pastoris. Nonconventional Yeasts in Biotechnology,In: Wolf K. (Ed.), Springer, Berlin, pp. 203–253
Stahmann, K.-P., Revuelta, J.L. and Seulberger, H. 2000. Appl. Microbiol. Biotechnol. 53: 509–516.
Tanner, F., Voinovich, C. and van Lanen, J.M. 1945. Science 101: 180–181.
Tavares, J.M., Duarte, L.C., Amaral-Collaco, M.T. and Girio, F. M. 2000. Enz. Microb. Technol. 26: 743–747.
van den Tempel, T. and Jacobsen, M. 2000. Int. Dairy J. 10: 263–270.
Tilburn, J., Roussel, F. and Scazzocchio, C. 1990. Genetics 126: 81–90.
Thome, P.E. 2004. Yeast 21: 119–126.
Thome, P.E. 2007. Antonie Van Leeuwenhoek 91: 229–235.
Thome, P.E. and Trench, R.K. 1999. Mar. Biotechnol. (NY) 1: 230–238.
Veiga, A., Arrabaca, J.D., and Loureiro-Dias, M.C. 2003a. J. Appl. Microbiol. 95: 364–371.
Veiga, A., Arrabaca, J.D., Sansonetty, F., Ludovico P., Corte-Real, M. and Loureiro-Dias, M.C.2003b FEMS Yeast Res. 3: 141–148.
Velkova, K. and Sychrova, H. 2006. Gene 369: 27–34.
Voronovsky, A.Y., Abbas, C.A., Dmytruk, K.V., Ishchuk, O.P., Kshanovska, B.V., Sybirna, K.A.,Gaillardin, C. and Sibirny, A.A. 2004. Yeast 21: 1307–1316.
Voronovsky, A., Abbas, C.A., Fayura, L.R., Kshanovska, B.V., Dmytruk, K.V., Sybirna, K.A. and Sibirny, A.A. 2002. FEMS Yeast Res. 2: 381–388.
van der Walt, J.P. Taylor, M.B., and Liebenberg, N.V. 1977. Antonie Van Leeuwenhoek 43: 205–218.
Welthagen, J.J. and Viljoen, B.C. 1998. Int. J. Food Microbiol. 41: 185–194.
Wyder, M.-T. and Puhan, Z. 1999. Int. Dairy J. 9: 117–124.
Yadav, J.S. and Loper, J.C. 1999. Gene 226: 139–146.
Yanai, T. and Sato, M. 1999. Am. J. Enol. Viticult. 50: 231–235.
Yanai, T., Tsunekawa, H., Okamura, K. and Okamoto, R. 1994. JP Patent No 0600091.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2009 Springer Science + Business Media B.V
About this chapter
Cite this chapter
Sibirny, A.A., Voronovsky, A.Y. (2009). Candida famata (Debaryomyces hansenii) . In: Satyanarayana, T., Kunze, G. (eds) Yeast Biotechnology: Diversity and Applications. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-8292-4_5
Download citation
DOI: https://doi.org/10.1007/978-1-4020-8292-4_5
Publisher Name: Springer, Dordrecht
Print ISBN: 978-1-4020-8291-7
Online ISBN: 978-1-4020-8292-4
eBook Packages: Chemistry and Materials ScienceChemistry and Material Science (R0)