Skip to main content
SpringerLink
Log in

Arxula adeninivorans (Blastobotrys adeninivorans) — A Dimorphic Yeast of Great Biotechnological Potential

  • Chapter
Yeast Biotechnology: Diversity and Applications

The dimorphic ascomycetous yeast Arxula adeninivorans exhibits some unusual properties. Being a thermo- and halotolerant species it is able to assimilate and ferment many compounds as sole carbon and/or nitrogen source. It utilises n-alkanes and is capable of degrading starch. Due to these unusual biochemical properties A. adeninivorans can be exploited as a gene donor for the production of enzymes with attractive biotechnological characteristics. Examples of A. adeninivorans-derived genes that are overexpressed include the ALIP1 gene encoding a secretory lipase, the AINV encoding invertase, the AXDH encoding xylitol dehydrogenase and the APHY encoding a secretory phosphatase with phytase activity.

The thermo- and halotolerance as well as differential morphology-dependent glycosylation and the secretion characteristics render A. adeninivorans attractive as host for heterologous gene expression. A transformation system has been established based on homologous integration of linearised DNA fragments. Successful expression examples like that of the E. coli-derived lacZ gene, GFP and human HSA and IL6 genes add to the attraction of A. adeninivorans as host for hetero logous gene expression.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 259.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 329.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 329.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Böer, E., Gellissen, G. and Kunze, G. 2005a. Arxula adeninivorans In: (Ed. Gellissen, G.,) Production of Recombinant Proteins. Novel Microbial and Eukaryotic Expression Systems, WILEY-VCH Verlag GmbH & Co. KGaA.

    Google Scholar 

  • Böer, E., Mock, H.-P., Bode, R., Gellissen, G. and Kunze, G. 2005b. Yeast 22: 523–535.

    Article  CAS  Google Scholar 

  • B ö er, E., Steinborn, G., Matros, A., Mock, H.P., Gellissen, G. and G, K. 2007. FEMS Yeast Res.: (in press).

    Google Scholar 

  • Böer, E., Wartmann, T., Dlubatz, K., Gellissen, G. and Kunze, G. 2004a. Curr. Genet. 46: 269–276.

    Article  CAS  Google Scholar 

  • Böer, E., Wartmann, T., Luther, B., Manteuffel, R., Bode, R., Gellissen, G. and Kunze, G. 2004b. Antonie van Leeuwenhoek 86: 121–134.

    Article  Google Scholar 

  • Böer, E., Wartmann, T., Schmidt, S., Bode, R., Gellissen, G. and Kunze, G. 2005c. Antonie van Leeuwenhoek 87: 233–243.

    Article  CAS  Google Scholar 

  • Böttcher, F., Klinner, U., Köhler, M., Samsonova, I.A., Kapultsevich, J. and Bliznik, X. 1988. Verfahren zur Futterhefeproduktion in zuckerhaltigen Medien. DD 278 354 A1.

    Google Scholar 

  • B ö ttcher, F. and Samsonova, I.A. 1983. Systemische Fungizide und antifungale Verbindungen In: Lyr, H. and Polter, C. (Eds.), Systemische Fungizide und antifungale Verbindungen, Akademie Verlag, pp. 255 –258.

    Google Scholar 

  • Bui, D.M., Kunze, I., Förster, S., Wartmann, T., Horstmann, C., Manteuffel, R. and Kunze, G. 1996a. Appl. Microbiol. Biotechnol. 44: 610–619.

    Article  CAS  Google Scholar 

  • Bui, D.M., Kunze, I., Horstmann, C., Schmidt, T. and Breunig, K.D. 1996b. Appl. Microbiol. Biotechnol. 45: 102–106.

    Article  CAS  Google Scholar 

  • Büttner, R. and Bode, R. 1992. J. Basic Microbiol. 32: 159–166.

    Article  Google Scholar 

  • Büttner, R., Bode, R. and Birnbaum, D. 1987. J. Basic Microbiol. 27: 299–308.

    Article  Google Scholar 

  • Büttner, R., Bode, R. and Birnbaum, D. 1988. Acta Biotechnol. 8: 517–525.

    Article  Google Scholar 

  • Büttner, R., Bode, R. and Birnbaum, D. 1989. J. Basic Microbiol. 30: 227–231.

    Article  Google Scholar 

  • Büttner, R., Bode, R. and Birnbaum, D. 1990a. Wiss. Z. Ernst-Moritz-Arndt-Univ. Greifswald, Math.-nat.wiss. Reihe 39: 1–21.

    Google Scholar 

  • Büttner, R., Bode, R., Samsonova, I.A. and Birnbaum, D. 1990b. J. Basic Microbiol. 30: 227 – 231.

    Article  Google Scholar 

  • Büttner, R., Schubert, U., Bode, R. and Birnbaum, D. 1990c. Acta Biotechnol. 10: 361–370.

    Article  Google Scholar 

  • Büttner, R., Bode, R. and Birnbaum, D. 1991a. J. Basic Microbiol. 31: 423–428.

    Article  Google Scholar 

  • Büttner, R., Bode, R. and Birnbaum, D. 1991b. Zbl. Mikrobiol. 146: 399–406.

    Google Scholar 

  • Büttner, R., Bode, R. and Birnbaum, D. 1992a. Zbl. Mikrobiol. 147: 237–242.

    Google Scholar 

  • Büttner, R., Bode, R. and Birnbaum, D. 1992b. Zbl. Mikrobiol. 147: 291–296.

    Google Scholar 

  • El Fiki, A., El Metabteb, G., Bellebna, C., Wartmann, T., Bode, R. and Gellissen, G. and G, K. 2007. Appl. Microbiol. Biotechnol. (in press).

    Google Scholar 

  • Gellissen, G. 2005. Production of recombinant proteins - novel microbial and eukaryotic expression systems, WILEY-VCH Verlag GmbH & Co. KGaA.

    Google Scholar 

  • Gellissen, G., Kunze, G., Gaillardin, C., Cregg, J.M., Berardi, E., Veenhuis, M. and van der Klei, I. 2005. FEMS Yeast Res. 5: 1079–1096.

    Article  CAS  Google Scholar 

  • Gienow, U., Kunze, G., Schauer, F., Bode, R. and Hofemeister, J. 1990. Zbl. Mikrobiol. 145: 3 – 12.

    CAS  Google Scholar 

  • Hahn, T., Tag, K., Riedel, K., Uhlig, S., Baronian, K., Gellissen, G. and Kunze, G. 2006. Biosens. Bioelectron. 21: 2078–2085.

    CAS  Google Scholar 

  • Kaur, P., Lingner, A., Singh, B., Böer, E., Polajeva, J., Steinborn, G., Bode, R., Gellissen, G. and Kunze, G. 2007. Antonie van Leeuwenhoek 91: 45–55.

    Article  CAS  Google Scholar 

  • Kunze, G., Pich, U., Lietz, K., Barner, A., B ü ttner, R., Bode, R., Conrad, U., Samsonova, I.A. and Schmidt, H. 1990. Wirts-Vektor-System und Verfahren zu seiner Herstellung. DD 298 821 A5.

    Google Scholar 

  • Kunze, G. and Kunze, I. 1994a. Antonie van Leeuwenhoek 65: 29–34.

    Article  CAS  Google Scholar 

  • Kunze, G. and Kunze, I. 1996. Arxula adeninivorans In: Wolf, K. (Ed), Nonconventional yeasts in biotechnology, Springer-Verlag, pp. 389 –409.

    Google Scholar 

  • Kunze, I. and Kunze, G. 1994b. J. Eur. Microbiol. 212: 24–28.

    Google Scholar 

  • Kurtzmann, C.P. and Robnett, J.C. 2007. FEMS Yeast Res. 7: 141–151.

    Article  CAS  Google Scholar 

  • Middelhoven, W.J. 1993. Antonie van Leeuwenhoek 63: 125–144.

    Article  CAS  Google Scholar 

  • Middelhoven, W.J., Coenen, A., Kraakman, B. and Sollewijn Gelpke, M.D. 1992. Antonie van Leeuwenhoek 62: 181–187.

    Article  CAS  Google Scholar 

  • Middelhoven, W.J., de Jong, I.M. and Winter, M. 1991. Antonie van Leeuwenhoek 60: 129–137.

    Article  Google Scholar 

  • Middelhoven, W.J., Hoogkamer-Te Niet, M.C. and Kreger-Van Rij, N.J.W. 1984. Antonie van Leeuwenhoek 50: 369–378.

    Article  CAS  Google Scholar 

  • Middelhoven, J. and van Doesburg, W. 2007. Antonie van Leeuwenhoek 91: 191–196.

    Article  CAS  Google Scholar 

  • Rösel, H. and Kunze, G. 1995. Curr. Genet. 28: 360–366.

    Article  Google Scholar 

  • Rösel, H. and Kunze, G. 1996. Yeast 12: 1201–1208.

    Article  Google Scholar 

  • Rösel, H. and Kunze, G. 1998. Curr. Genet. 33: 157–163.

    Article  Google Scholar 

  • Samsonova, I.A., Böttcher, F., Werner, C. and Bode, R. 1989. J. Basic Microbiol. 29: 675–683.

    Article  CAS  Google Scholar 

  • Samsonova, I.A., Kunze, G., Bode, R. and Böttcher, F. 1996. Yeast 12: 1209–1217.

    Article  CAS  Google Scholar 

  • Sano, K., Fukuhara, H. and Nakamura, Y. 1999. Biotechnol. Lett. 21: 33–38.

    Article  CAS  Google Scholar 

  • Steinborn, G., Gellissen, G. and Kunze, G. 2005. FEMS Yeast Res. 5: 1047–1054.

    Article  CAS  Google Scholar 

  • Steinborn, G., Gellissen, G. and Kunze, G. 2007a. FEMS Yeast Res. (in press).

    Google Scholar 

  • Steinborn, G., Wartmann, T., Gellissen, G. and Kunze, G. 2007b. J. Biotechnol. 127: 392–401.

    Article  CAS  Google Scholar 

  • Stoltenburg, R., Lösche, O., Klappach, G. and Kunze, G. 1999. Curr. Genet. 35: 8–13.

    Article  CAS  Google Scholar 

  • Tanaka, A., Ohnishi, N. and Fuki, S. 1967. J. Ferment. Technol. 45: 617–623.

    CAS  Google Scholar 

  • Terentiev, Y., Breuer, U., Babel, W. and Kunze, G. 2004. Appl. Microbiol. Biotechnol. 64: 376–381.

    Article  CAS  Google Scholar 

  • Van der Walt, J.P., Smith, M.T. and Yamada, Y. 1990. Antonie van Leeuwenhoek 57: 59–61.

    Article  Google Scholar 

  • Wartmann, T., Bellebna, C., Böer, E., Bartelsen, O., Gellissen, G. and Kunze, G. 2003a. Appl. Microbiol. Biotechnol. 62: 528–535.

    Article  CAS  Google Scholar 

  • Wartmann, T., Böer, E., Pico, A.H., Sieber, H., Bartelsen, O., Gellissen, G. and Kunze, G. 2002a. FEMS Yeast Res. 2: 363–369.

    CAS  Google Scholar 

  • Wartmann, T., Erdmann, J. and Kunze, I. 2000. Arch. Microbiol. 173: 253–261. Wartmann, T., Gellissen, G. and Kunze, G. 2001. Curr. Genet. 40: 172–178.

    Article  CAS  Google Scholar 

  • Wartmann, T., Gellissen, G. and Kunze, G. 2001. Curr. Genet. 40: 172–178

    Article  CAS  Google Scholar 

  • Wartmann, T., Krüger, A., Adler, K., Bui, M.D., Kunze, I. and Kunze G. 1995a. Antonie van Leeuwenhoek 68: 215–223.

    Article  CAS  Google Scholar 

  • Wartmann, T. and Kunze, G. 2000. Appl. Microbiol. Biotechnol. 54: 619–624.

    Article  CAS  Google Scholar 

  • Wartmann, T. and Kunze, G. 2003. Expression of the HSA and GFP gene in budding cells and mycelia of A. adeninivorans In: Non-Conventional Yeasts in Genetics, Biochemistry and Biotechnology (Eds. Wolf, K., Breunig, K. and Barth, G.), Springer-Verlag.

    Google Scholar 

  • Wartmann, T., Kunze, I., Duc, B.M., Manteuffel, R. and Kunze, G. 1995b. Microbiol. Res. 150: 113–120.

    CAS  Google Scholar 

  • Wartmann, T., Rösel, H., Kunze, I., Bode, R. and Kunze, G. 1998. Yeast 14: 1017–1025.

    Article  CAS  Google Scholar 

  • Wartmann, T., Stephan, U.W., Bube, I., Böer, E., Melzer, M., Manteuffel, R., Stoltenburg, R., Guengerich, L., Gellissen, G. and Kunze, G. 2002b. Yeast 19: 849–862.

    Article  CAS  Google Scholar 

  • Wartmann, T., Stoltenburg, R., Böer, E., Sieber, H., Bartelsen, O., Gellissen, G. and Kunze, G. 2003b. FEMS Yeast Res. 3: 223–232.

    Article  CAS  Google Scholar 

  • Wolf, K. 1996. Nonconventional yeasts in biotechnology, Springer-Verlag.

    Google Scholar 

  • Wolf, K., Breunig, K. and Barth, G. 2003. Non-conventional yeasts in genetics, biochemistry and biotechnology, Springer-Verlag.

    Google Scholar 

  • Yang, X.-X., Wartmann, T., Stoltenburg, R. and Kunze, G. 2000. Antonie van Leeuwenhoek 77: 303–311.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Leibniz-Institut für Pflanzengenetik und Kulturpflanzenforschung, Corrensstr 3, Gatersleben, D-06466, Germany

    Erik Böer & Martina Körner

  2. PharmedArtis GmbH, Forckenbeckstr. 6, Aachen, 52074, Germany

    Gerd Gellissen

  3. Institute of Plant Genetics and Crop Plant Research, Leibniz Institute, Correnstrasse 3, Gatersleben, D-06466, Germany

    Gotthard Kunze

Authors
  1. Erik Böer
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Gerhard Steinborn
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Kristina Florschütz
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Martina Körner
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Gerd Gellissen
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Gotthard Kunze
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Microbiology, University of Delhi, South Campus, New Delhi-110021, India

    T. Satyanarayana

  2. Institute of Plant Genetics and Crop Plant Research, Leibniz Institute, Corenstrasse 3, Gatersleben, D-06466, Germany

    Gotthard Kunze

Rights and permissions

Reprints and permissions

Copyright information

© 2009 Springer Science + Business Media B.V

About this chapter

Cite this chapter

Böer, E., Steinborn, G., Florschütz, K., Körner, M., Gellissen, G., Kunze, G. (2009). Arxula adeninivorans (Blastobotrys adeninivorans) — A Dimorphic Yeast of Great Biotechnological Potential. In: Satyanarayana, T., Kunze, G. (eds) Yeast Biotechnology: Diversity and Applications. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-8292-4_27

Download citation

Publish with us

Policies and ethics

Search

Navigation