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Molecular Chaperones and Protection in Animal and Cellular Models of Ischemic Stroke

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Heat Shock Proteins and the Brain: Implications for Neurodegenerative Diseases and Neuroprotection

Part of the book series: Heat Shock Proteins ((HESP,volume 3))

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Abstract

Chaperones, including heat-shock proteins (Hsps) Hsp70, Hsp40 and GroEL, has been shown to protect from both global and focal ischemia in vivo and cell culture models of ischemia/reperfusion injury in vitro. While the mechanism of protection in part reflects chaperone functions (i.e., preventing abnormal protein folding or aggregation), work from our laboratory and others has implicated additional mechanisms including direct interference with cell death pathways, modulation of inflammation, and preservation of mitochondrial function. In this chapter we will first briefly introduce the Hsps, then describe the animal and cellular models of cerebral ischemia in which effects of Hsps have been studied, including reviewing methods used to overexpress Hsps. We will focus on the protective effect of overexpressing different Hsps against ischemic stroke and elaborate the potential mechanisms involved. Despite a great deal of study, much remains to be learned about the multifaceted effects of Hsps in cerebral ischemia. The endogenous stress response remains a model of cell protection with promise for the development of novel therapies for ischemic brain injury

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Authors and Affiliations

  1. Department of Anesthesia, Stanford University School of Medicine, Stanford, CA, USA

    Yi-Bing Ouyang, Lijun Xu & Rona G. Giffard

  2. Department of Anesthesia, Stanford University School of Medicine, 300 Pasteur Drive, Grant Building S272, Stanford, CA 94305-5117, USA

    Rona G. Giffard

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  1. Yi-Bing Ouyang
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  2. Lijun Xu
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  3. Rona G. Giffard
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Editors and Affiliations

  1. Effie and Wofford Cain Centennial Endowed Chair in Clinical Pathology, Chief, Division of Investigative Pathology, Scott & White Memorial Hospital and Clinic and The Texas A&M Health Science Center College of Medicine, Temple, Texas, U.S.A

    Alexzander A.A. Asea

  2. Department of Biological Sciences, Center for the Neurobiology of Stress, University of Toronto at Scarborough, Toronto, ON, Canada

    Ian R. Brown

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Ouyang, YB., Xu, L., Giffard, R.G. (2008). Molecular Chaperones and Protection in Animal and Cellular Models of Ischemic Stroke. In: Asea, A.A., Brown, I.R. (eds) Heat Shock Proteins and the Brain: Implications for Neurodegenerative Diseases and Neuroprotection. Heat Shock Proteins, vol 3. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-8231-3_9

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